ReviewOncogene2000
Transforming growth factor alpha- and c-myc-induced mammary carcinogenesis in transgenic mice.
Review in Oncogene, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 42 citations in OpenAlex.
- A mouse model for the study of anti-tumor T cell responses in Kras-driven lung adenocarcinoma.Cell reports methods · 2021Article
- Breast cancer animal models and applications.Zoological research · 2020Review
- Molecular characterizations of Nop16 in murine mammary tumors with varying levels of c-Myc.Transgenic research · 2012Article
- Tumor suppressor function of Liver kinase B1 (Lkb1) is linked to regulation of epithelial integrity.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Hyperinsulinemia enhances c-Myc-mediated mammary tumor development and advances metastatic progression to the lung in a mouse model of type 2 diabetes.Breast cancer research : BCR · 2012Article
- MRI methods for evaluating the effects of tyrosine kinase inhibitor administration used to enhance chemotherapy efficiency in a breast tumor xenograft model.Journal of magnetic resonance imaging : JMRI · 2009Article
- Review
- Progesterone and breast cancer.Women's health (London, England) · 2008Review
- Estrogen receptor-positive mammary tumorigenesis in TGFalpha transgenic mice progresses with progesterone receptor loss.Oncogene · 2007Article
- Mammary carcinogenesis is preceded by altered epithelial cell turnover in transforming growth factor-alpha and c-myc transgenic mice.The American journal of pathology · 2006Article
- MET and MYC cooperate in mammary tumorigenesis.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Proteotypic classification of spontaneous and transgenic mammary neoplasms.Breast cancer research : BCR · 2004Article
- Strain background alters mammary gland lesion phenotype in transforming growth factor-alpha transgenic mice.The American journal of pathology · 2002Article
- Maspin expression inversely correlates with breast tumor progression in MMTV/TGF-alpha transgenic mouse model.Oncogene · 2001Article
- Myc and mammary cancer: Myc is a downstream effector of the ErbB2 receptor tyrosine kinase.Journal of mammary gland biology and neoplasia · 2001Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The growth factor transforming growth factor alpha (TGFalpha) and the nuclear transcription factor c-myc often are overexpressed by human breast cancer cells. To produce models of breast disease with these etiologies, mice were generated that carried TGF-alpha- or c-myc-encoding transgenes. Transgene targeting employed the whey acidic protein (WAP) gene promoter, which is expressed in pregnant and lactating mammary epithelial cells. Non-virgin WAP-TGFalpha transgenic mice displayed accelerated mammary development during pregnancy, delayed post-parturient mammary involution, a progressive increase in the number of hyperplastic alveolar nodules (HANs), and development of mammary carcinoma with a mean latency of 9 months. Non-virgin WAP-c-myc transgenic mice displayed accelerated mammary gland development during pregnancy and development of mammary carcinomas with a latency of 8 months. Bitransgenic mice carrying both WAP-TGFalpha and WAP-c-myc displayed a dramatic acceleration of tumor development. These models identify the overexpression of TGFalpha or c-myc as etiological factors in the development of mammary neoplasia and demonstrate the increased severity of disease when both molecular alterations are present in the same cell.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.