ReviewOncogene2000
Dual regulation of proliferation and apoptosis: c-myc in bitransgenic murine mammary tumor models.
Review in Oncogene, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 45 citations in OpenAlex.
- Knockdown of DEAD-box RNA helicase 52 (DDX52) suppresses the proliferation of melanoma cells in vitro and of nude mouse xenografts by targeting c-Myc.Bioengineered · 2021Article
- BRD4 modulates vulnerability of triple-negative breast cancer to targeting of integrin-dependent signaling pathways.Cellular oncology (Dordrecht, Netherlands) · 2020Article
- eIF4E is an adverse prognostic marker of melanoma patient survival by increasing melanoma cell invasion.The Journal of investigative dermatology · 2015Article
- c-Myc suppresses microRNA-29b to promote tumor aggressiveness and poor outcomes in non-small cell lung cancer by targeting FHIT.Oncogene · 2015Article
- Article
- Estrogen up-regulates ATBF1 transcription but causes its protein degradation in estrogen receptor-alpha-positive breast cancer cells.The Journal of biological chemistry · 2011Article
- Article
- KLF6 induces apoptosis in prostate cancer cells through up-regulation of ATF3.The Journal of biological chemistry · 2008Article
- c-myc amplifications in primary breast carcinomas and their local recurrences.Journal of clinical pathology · 2006Article
- Bax regulates c-Myc-induced mammary tumour apoptosis but not proliferation in MMTV-c-myc transgenic mice.British journal of cancer · 2004Article
- Of mice and Myc: c-Myc and mammary tumorigenesis.Journal of mammary gland biology and neoplasia · 2004Review
- Article
- Progression to malignancy in the polyoma middle T oncoprotein mouse breast cancer model provides a reliable model for human diseases.The American journal of pathology · 2003Article
- Prolactin induces ERalpha-positive and ERalpha-negative mammary cancer in transgenic mice.Oncogene · 2003Article
- Interrogating mouse mammary cancer models: insights from gene expression profiling.Journal of mammary gland biology and neoplasia · 2003Review
- Pronounced reduction in adenoma recurrence associated with aspirin use and a polymorphism in the ornithine decarboxylase gene.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- CpG oligodeoxynucleotide 5mer-induced apoptosis in MOLT-4 leukaemia cells does not require caspase 3 or new protein synthesis.Nucleic acids research · 2003Article
- Effect of Helicobacter pylori on apoptosis and apoptosis related genes in gastric cancer cells.Molecular pathology : MP · 2003Article
- Article
- Expression of c-myc is not critical for cell proliferation in established human leukemia lines.BMC molecular biology · 2001Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Recent progress in the study of c-Myc has convincingly demonstrated that it possesses a dual role in regulating both proliferation and apoptosis; however, the manner in which c-Myc influences these cellular response pathways remains incompletely characterized. Deregulation of c-Myc expression, via many mechanisms, is a common feature of multiple cancers and is an especially prominent feature of many breast cancers. Of significant interest to those who study mammary gland development and neoplasia is the unresolved nature and contribution of apoptosis to breast tumorigenesis. Recently, the use of transgenic mice and gene-knockout mice has allowed investigators to evaluate the pathological mechanisms by which different genes influence tumor development and progression. In this review, we address two distinct c-myc-containing bitransgenic murine mammary tumor models and discuss the contribution and possible future directions for resolution of cancer-relevant molecular pathways influenced by c-Myc.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.