ArticleMolecular and cellular biology2000
Involvement of the checkpoint protein Mec1p in silencing of gene expression at telomeres in Saccharomyces cerevisiae.
Article in Molecular and cellular biology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31 citing papers in PubMed, 52 citations in OpenAlex.
- Checkpoint and recombination pathways independently suppress rates of spontaneous homology-directed chromosomal translocations in budding yeast.Frontiers in genetics · 2025Article
- Functional interplay between the oxidative stress response and DNA damage checkpoint signaling for genome maintenance in aerobic organisms.Journal of microbiology (Seoul, Korea) · 2020Review
- Yeast Dun1 Kinase Regulates Ribonucleotide Reductase Small Subunit Localization in Response to Iron Deficiency.The Journal of biological chemistry · 2016Article
- Yeast Dun1 kinase regulates ribonucleotide reductase inhibitor Sml1 in response to iron deficiency.Molecular and cellular biology · 2014Article
- Activation of protein kinase C-mitogen-activated protein kinase signaling in response to inositol starvation triggers Sir2p-dependent telomeric silencing in yeast.The Journal of biological chemistry · 2013Article
- Article
- A common telomeric gene silencing assay is affected by nucleotide metabolism.Molecular cell · 2011Article
- Differential nuclear localization does not determine the silencing status of Saccharomyces cerevisiae telomeres.Genetics · 2007Article
- The Saccharomyces cerevisiae 14-3-3 proteins Bmh1 and Bmh2 directly influence the DNA damage-dependent functions of Rad53.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Article
- Inactivation of Ku-mediated end joining suppresses mec1Delta lethality by depleting the ribonucleotide reductase inhibitor Sml1 through a pathway controlled by Tel1 kinase and the Mre11 complex.Molecular and cellular biology · 2005Article
- Regulation of histone deposition proteins Asf1/Hir1 by multiple DNA damage checkpoint kinases in Saccharomyces cerevisiae.Genetics · 2005Article
- Drosophila ATM and ATR checkpoint kinases control partially redundant pathways for telomere maintenance.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Drosophila atm/telomere fusion is required for telomeric localization of HP1 and telomere position effect.Genes & development · 2004Article
- Saccharomyces cerevisiae Dap1p, a novel DNA damage response protein related to the mammalian membrane-associated progesterone receptor.Eukaryotic cell · 2003Article
- Direct kinase-to-kinase signaling mediated by the FHA phosphoprotein recognition domain of the Dun1 DNA damage checkpoint kinase.Molecular and cellular biology · 2003Article
- A dominant-negative MEC3 mutant uncovers new functions for the Rad17 complex and Tel1.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- MEC3, MEC1, and DDC2 are essential components of a telomere checkpoint pathway required for cell cycle arrest during senescence in Saccharomyces cerevisiae.Molecular biology of the cell · 2002Article
- Regulation of genome stability by TEL1 and MEC1, yeast homologs of the mammalian ATM and ATR genes.Genetics · 2002Article
- Suppression of genome instability by redundant S-phase checkpoint pathways in Saccharomyces cerevisiae.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Yeast strains with a mutation in the MEC1 gene are deficient in the cellular checkpoint response to DNA-damaging agents and have short telomeres (K. B. Ritchie, J. C. Mallory, and T. D. Petes, Mol. Cell. Biol. 19:6065-6075, 1999; T. A. Weinert, G. L. Kiser, and L. H. Hartwell, Genes Dev. 8:652-665, 1994). In wild-type yeast cells, genes inserted near the telomeres are transcriptionally silenced (D. E. Gottschling, O. M. Aparichio, B. L. Billington, and V. A. Zakian, Cell 63:751-762, 1990). We show that mec1 strains have reduced ability to silence gene expression near the telomere. This deficiency was alleviated by the sml1 mutation. Overexpression of Mec1p also resulted in a silencing defect, although this overexpression did not affect the checkpoint function of Mec1p. Telomeric silencing was not affected by mutations in several other genes in the Mec1p checkpoint pathway (null mutations in RAD9 and CHK1 or in several hypomorphic rad53 alleles) but was reduced by a null mutation of DUN1. In addition, the loss of telomeric silencing in mec1 strains was not a consequence of the slightly shortened telomeres observed in these strains.
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