ArticleAmerican journal of human genetics2000
Significant admixture linkage disequilibrium across 30 cM around the FY locus in African Americans.
Article in American journal of human genetics, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 93 citations in OpenAlex.
- Trial
- Genomic Predictors of Asthma Phenotypes and Treatment Response.Frontiers in pediatrics · 2019Review
- Local Ancestry Association, Admixture Mapping, and Ongoing Challenges.Circulation. Cardiovascular genetics · 2017Article
- Human population admixture in Asia.Genomics & informatics · 2012Article
- Article
- Genome-wide scans for footprints of natural selection.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2010Review
- Admixture mapping comes of age.Annual review of genomics and human genetics · 2010Review
- A common polymorphism in serotonin receptor 1B mRNA moderates regulation by miR-96 and associates with aggressive human behaviors.Molecular psychiatry · 2009Article
- The value of some Corsican sub-populations for genetic association studies.BMC medical genetics · 2008Article
- Duffy antigen receptor for chemokines mediates trans-infection of HIV-1 from red blood cells to target cells and affects HIV-AIDS susceptibility.Cell host & microbe · 2008Article
- Recent genetic selection in the ancestral admixture of Puerto Ricans.American journal of human genetics · 2007Article
- Article
- A classical likelihood based approach for admixture mapping using EM algorithm.Human genetics · 2006Article
- Race, ethnicity and prevalence of primary open-angle glaucoma.Journal of the National Medical Association · 2006Article
- A genomewide single-nucleotide-polymorphism panel with high ancestry information for African American admixture mapping.American journal of human genetics · 2006Article
- Assessing the relative ages of admixture in the bovine hybrid zones of Africa and the Near East using X chromosome haplotype mosaicism.Genetics · 2006Article
- Bone mineral density-affecting genes in Africans.Journal of the National Medical Association · 2006Article
- Population stratification confounds genetic association studies among Latinos.Human genetics · 2006Article
- Admixture mapping as a gene discovery approach for complex human traits and diseases.Current hypertension reports · 2005Review
- Mutation history of the roma/gypsies.American journal of human genetics · 2004Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Scientists, to understand the importance of allelic polymorphisms on phenotypes that are quantitative and environmentally interacting, are now turning to population-association screens, especially in instances in which pedigree analysis is difficult. Because association screens require linkage disequilibrium between markers and disease loci, maximizing the degree of linkage disequilibrium increases the chances of discovering functional gene-marker associations. One theoretically valid approach-mapping by admixture linkage disequilibrium (MALD), using recently admixed African Americans-is empirically evaluated here by measurement of marker associations with 15 short tandem repeats (STRs) and an insertion/deletion polymorphism of the AT3 locus in a 70-cM segment at 1q22-23, around the FY (Duffy) locus. The FY polymorphism (-46T-->C) disrupts the GATA promoter motif, specifically blocking FY erythroid expression and has a nearly fixed allele-frequency difference between European Americans and native Africans that is likely a consequence of a selective advantage of FY-/- in malaria infections. Analysis of linkage disequilibrium around the FY gene has indicated that there is strong and consistent linkage disequilibrium between FY and three flanking loci (D1S303, SPTA1, and D1S484) spanning 8 cM. We observed significant linkage-disequilibrium signals over a 30-cM region from -4.4 to 16.3 cM (from D1S2777 to D1S196) for STRs and at 26.4 cM (AT3), which provided quantitative estimates of centimorgan limits, by MALD assessment in African American population-association analyses, of 5-10 cM.
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