ArticleDigestive diseases and sciences2000
Evidence that colitis is initiated by environmental stress and sustained by fecal factors in the cotton-top tamarin (Saguinus oedipus).
Article in Digestive diseases and sciences, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 61 citations in OpenAlex.
- New World Primates and Their Human Counterparts Share Diseases That Abound with CEACAM and Other Effector Molecules.Life (Basel, Switzerland) · 2025Review
- Changes in the faecal microbiome of pied tamarins (Saguinus bicolor) associated with chronic, recurrent diarrhoea and weight loss.Animal microbiome · 2021Article
- Non-Human Primate Models of Dengue Virus Infection: A Comparison of Viremia Levels and Antibody Responses during Primary and Secondary Infection among Old World and New World Monkeys.Pathogens (Basel, Switzerland) · 2020Review
- Behavioural medicine and gastrointestinal disorders: the promise of positive psychology.Nature reviews. Gastroenterology & hepatology · 2018Review
- GRG Profiles: Jackie D. Wood.Digestive diseases and sciences · 2016Article
- Avoiding hepatic metastasis naturally: Lessons from the cotton top tamarin (Saguinus oedipus).World journal of gastroenterology · 2016Review
- Animal models to study acute and chronic intestinal inflammation in mammals.Gut pathogens · 2015Review
- Psychological disorders in gastrointestinal disease: epiphenomenon, cause or consequence?Annals of gastroenterology · 2014Article
- Animal models of colorectal cancer.Cancer metastasis reviews · 2013Review
- Reconsidering the methodology of "stress" research in inflammatory bowel disease.Journal of Crohn's & colitis · 2008Article
- Neuropathophysiology of functional gastrointestinal disorders.World journal of gastroenterology · 2007Review
- Distribution and chemical coding of corticotropin-releasing factor-immunoreactive neurons in the guinea pig enteric nervous system.The Journal of comparative neurology · 2006Article
- Review
- Radical induction theory of ulcerative colitis.World journal of gastroenterology · 2005Review
- A study of the effects of restraint stress on colitis induced by dextran sulphate sodium in singly housed rats.Integrative physiological and behavioral science : the official journal of the Pavlovian SocietyArticle
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
Parallel changes in spontaneously occurring inflammation in colonic Thiry-Vella loops and the in-line colon of cotton-top tamarins were studied in a colitis-inducing environment at 8 and 15 months following surgical preparation of the loops. Gross disease severity and numbers of inflammatory/immune cells per unit area of lamina propria in histological sections from endoscopic biopsies were analyzed. Cell counts and severity of colitis declined over time in the Thiry-Villa loops while the disease followed its characteristic course in the remaining large bowel and in the colons of controls. Perfusion of the loops with the animals' feces increased the density of the cellular infiltrate in the lamina propria in parallel with increased severity of inflammation. Electron micrographs of the colonic mucosa showed invasion by microorganisms. The predominant microorganism had characteristics of Helicobacter sp. The results implicate the fecal stream as a factor in the persistence of colitis in the tamarin model. Nevertheless, fecal factors appear not to be the primary trigger, as evidenced by findings that the disease is not expressed in wild-living tamarins and that it enters remission when affected animals are transferred to natural conditions from a colitis-inducing environment. Both an adverse environment and the fecal contents appear to be required for expression of the disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.