ArticleBritish journal of pharmacology2000
Mechanisms of 17 beta-oestradiol induced vasodilatation in isolated pressurized rat small arteries.
Article in British journal of pharmacology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 73 citations in OpenAlex.
- Gender-related differences in migraine.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020Review
- Structural analysis of estrogen receptors: interaction between estrogen receptors and cav-1 within the caveolae†.Biology of reproduction · 2019Article
- Estrogenic vascular effects are diminished by chronological aging.Scientific reports · 2017Article
- The Expanding Complexity of Estrogen Receptor Signaling in the Cardiovascular System.Circulation research · 2016Review
- Vasorelaxant effect of 17α-ethynylestradiol on human saphenous vein.Advanced pharmaceutical bulletin · 2015Article
- Human uterine and placental arteries exhibit tissue-specific acute responses to 17β-estradiol and estrogen-receptor-specific agonists.Molecular human reproduction · 2014Article
- 17β-Estradiol induces vasorelaxation in a G-protein-coupled receptor 30-independent manner.Naunyn-Schmiedeberg's archives of pharmacology · 2012Article
- Age-related changes in the contractile and passive arterial properties of murine mesenteric small arteries are altered by caveolin-1 knockout.Journal of cellular and molecular medicine · 2012Article
- Acute simvastatin increases endothelial nitric oxide synthase phosphorylation via AMP-activated protein kinase and reduces contractility of isolated rat mesenteric resistance arteries.Clinical science (London, England : 1979) · 2011Article
- Vasodilation in response to the GPR30 agonist G-1 is not different from estradiol in the mRen2.Lewis female rat.Journal of cardiovascular pharmacology · 2011Article
- GPER/GPR30 and Regulation of Vascular Tone and Blood Pressure.Immunology, endocrine & metabolic agents in medicinal chemistry · 2011Article
- Dilation of epicardial coronary arteries by the G protein-coupled estrogen receptor agonists G-1 and ICI 182,780.Pharmacology · 2010Article
- Estrogen replacement restores flow-induced vasodilation in coronary arterioles of aged and ovariectomized rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2009Article
- 17beta-estradiol attenuates vascular contraction through inhibition of RhoA/Rho kinase pathway.Naunyn-Schmiedeberg's archives of pharmacology · 2009Article
- Nongenomic responses to 17beta-estradiol in male rat mesenteric arteries abolish intrinsic gender differences in vascular responses.British journal of pharmacology · 2005Article
- 17beta-Estradiol inhibits calcium-dependent, but not calcium-independent, contraction in isolated rat aorta.Naunyn-Schmiedeberg's archives of pharmacology · 2005Article
- Comparison of U46619-, endothelin-1- or phenylephrine-induced changes in cellular Ca2+ profiles and Ca2+ sensitisation of constriction of pressurised rat resistance arteries.British journal of pharmacology · 2004Article
- Membrane associated estrogen receptors and related proteins: localization at the plasma membrane and the endoplasmic reticulum.Molecular and cellular biochemistry · 2003Review
- Acute effects of oestrogen receptor subtype-specific agonists on vascular contractility.British journal of pharmacology · 2003Article
- Effects of the oestrous cycle and gender on acute vasodilatory responses of isolated pressurized rat mesenteric arteries to 17 beta-oestradiol.British journal of pharmacology · 2001Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. The influence of 17 beta-oestradiol on pressurized isolated rat mesenteric and coronary small arteries was investigated. 2. 17 beta-oestradiol caused rapid (t1.0 < 5 mins) concentration-dependent relaxations of pre-contracted pressurized (50 mmHg) isolated rat mesenteric and coronary arteries. Similar responses were observed in both vessel types. Significant relaxations were only observed at concentrations exceeding 3 microM. 3. The vasodilatory responses in both types of artery were unaffected by 10 microM L-nitro arginine (L-NNA) alone or in the presence of 10 microM indomethacin, inhibitors of nitric oxide and prostaglandin synthesis respectively. They were also unaffected by the pre-contracting agent used i.e. high K+ or U46619 (a thromboxane analogue). 4. Neither the oestrogen receptor antagonist ICI 182,780 (10 microM) nor the protein synthesis inhibitor cycloheximide (100 microM) had any effect on the responses of mesenteric arteries to 17 beta-oestradiol. 5. 17 alpha-oestradiol had only a minor effect on mesenteric arterial diameter over a concentration range similar to the effective vasodilatory range for 17 beta-oestradiol. 6. Membrane impermeant 17 beta-oestradiol conjugated to bovine serum albumin (beta-oestradiol-17-hemisuccinate-BSA) (E-H-BSA) resulted in a vasodilatation of pressurized arteries. 7. Wortmannin, an inhibitor of myosin light chain kinase, near maximally relaxed pressurized mesenteric arteries although the time course for the response was significantly slower than that for 17 beta-oestradiol. 8. These results taken together suggest that the acute effects of 17 beta-oestradiol on isolated pressurized arterial tone may be due to effects directly on the vascular smooth muscle via non-genomic mechanisms that involve a stereospecific interaction at the plasma membrane.
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