Evidence map›Paper›PMID 10708445›Full record

ArticleJournal of virology2000

Virus-induced diabetes in a transgenic model: role of cross-reacting viruses and quantitation of effector T cells needed to cause disease.

N Sevilla, D Homann, M von Herrath, F Rodriguez, S Harkins, J L Whitton, M B Oldstone

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 52 citations in OpenAlex.

  1. One in Ten CD8Diabetes · 2021
    Article
  2. Review
  3. Review
  4. Review
  5. Braking bad: novel mechanisms of CTLA-4 inhibition of T cell responses.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2014
    Review
  6. Altered immune regulation in type 1 diabetes.Clinical & developmental immunology · 2013
    Review
  7. Viral infections and molecular mimicry in type 1 diabetes.APMIS : acta pathologica, microbiologica, et immunologica Scandinavica · 2012
    Review
  8. Virus infections in type 1 diabetes.Cold Spring Harbor perspectives in medicine · 2012
    Review
  9. Article
  10. Review
  11. Review
  12. Review
  13. Adenovirus E3 MHC inhibitory genes but not TNF/Fas apoptotic inhibitory genes expressed in beta cells prevent autoimmune diabetes.Proceedings of the National Academy of Sciences of the United States of America · 2009
    Article
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  15. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

N SevillaDivision of Virology, Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA.
D Homann
M von Herrath
F Rodriguez
S Harkins
J L Whitton
M B Oldstone
Scripps Research Institute · US

Funding

CYTOTOXIC T-CELL RESPONSES TO VIRUS INFECTIONR01AI027028 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI WHITTON, J. LINDSAY · 1989 to 2008
$3.5M
NEUROBIOLOGIC AND IMMUNOLOGIC ASPECTS OF AGINGT32AG000080 · NIA · SCRIPPS RESEARCH INSTITUTE · PI BUXBAUM, JOEL N · 1985 to 2003
$743k
Cytotoxic T Cell Responses to Virus InfectionR56AI027028 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI WHITTON, J. LINDSAY · 2012 to 2012
$474k
VIRUSES AND AUTOIMMUNE DISEASER01AI041439 · NIAID · SCRIPPS RESEARCH INSTITUTE · PI OLDSTONE, MICHAEL B · 1997 to 2001
$445k
ANALYSES OF CYTOTOXIC T CELL RESPONSE TO VIRUS INFECTIONR21AI027028 · NIAID · SCRIPPS RESEARCH INSTITUTE · PI WHITTON, J. LINDSAY · 1999 to 1999
–
NIAID NIH HHS AI27028NIAID NIH HHS AI41439NIAID NIH HHS R01 AI027028NIAID NIH HHS R21 AI027028NIAID NIH HHS R56 AI027028NIA NIH HHS T32 AG000080NIDDK NIH HHS DK995005
6 · The paper itself

Abstract

Virus-specific cytotoxic T lymphocytes (CTL) at frequencies of >1/1, 000 are sufficient to cause insulin-dependent diabetes mellitus (IDDM) in transgenic mice whose pancreatic beta cells express as "self" antigen a protein from a virus later used to initiate infection. The inability to generate sufficient effector CTL for other cross-reacting viruses that fail to cause IDDM could be mapped to point mutations in the CTL epitope or its COO(-) flanking region. These data indicate that IDDM and likely other autoimmune diseases are caused by a quantifiable number of T cells, that neither standard epidemiologic markers nor molecular analysis with nucleic acid probes reliably distinguishes between viruses that do or do not cause diabetes, and that a single-amino-acid change flanking a CTL epitope can interfere with antigen presentation and development of autoimmune disease in vivo.

Indexed as

Amino Acid SequenceAnimalsAntigens, ViralBase SequenceChlorocebus aethiopsCross ReactionsDiabetes Mellitus, Type 1Disease Models, AnimalDNA PrimersLymphocytic choriomeningitis virusMiceMice, TransgenicMolecular Sequence DataSequence Homology, Amino AcidT-LymphocytesVero CellsAntigens, ViralDNA Primers

Identifiers

PMID10708445
PMCPMC111829
OpenAlexW2138998130

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.