ArticleJournal of virology2000
Hypervariable region 1 sequence stability during hepatitis C virus replication in chimpanzees.
Article in Journal of virology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed.
- Hepatitis C hypervariable region 1: association of reduced selection pressure in african americans with treatment failure.Digestive diseases and sciences · 2007Trial
- Intra-host analysis of hepaciviral glycoprotein evolution reveals signatures associated with viral persistence and clearance.Virus evolution · 2022Article
- A polymorphic residue that attenuates the antiviral potential of interferon lambda 4 in hominid lineages.PLoS pathogens · 2018Article
- Hypervariable Region 1 in Envelope Protein 2 of Hepatitis C Virus: A Linchpin in Neutralizing Antibody Evasion and Viral Entry.Frontiers in immunology · 2018Review
- Next-generation sequencing analysis of a cluster of hepatitis C virus infections in a haematology and oncology center.PloS one · 2018Article
- Hepatitis C virus genotypes and subtypes circulating in Mainland China.Emerging microbes & infections · 2017Article
- Evolution of a cell culture-derived genotype 1a hepatitis C virus (H77S.2) during persistent infection with chronic hepatitis in a chimpanzee.Journal of virology · 2014Article
- Hepatitis C virus envelope glycoprotein fitness defines virus population composition following transmission to a new host.Journal of virology · 2012Article
- Transmission of clonal hepatitis C virus genomes reveals the dominant but transitory role of CD8⁺ T cells in early viral evolution.Journal of virology · 2011Article
- Review
- Hepatitis C virus evasion of adaptive immune responses: a model for viral persistence.Immunologic research · 2010Review
- Acceleration of hepatitis C virus envelope evolution in humans is consistent with progressive humoral immune selection during the transition from acute to chronic infection.Journal of virology · 2010Article
- Adaptive immunity to the hepatitis C virus.Advances in virus research · 2010Review
- Genetic divergence of hepatitis C virus: the role of HIV-related immunosuppression.Journal of acquired immune deficiency syndromes (1999) · 2008Article
- Immunoglobulin allotypes influence IgG antibody responses to hepatitis C virus envelope proteins E1 and E2.Human immunology · 2008Article
- Sequence diversity of hepatitis C virus: implications for immune control and therapy.World journal of gastroenterology · 2007Review
- Divergent and convergent evolution after a common-source outbreak of hepatitis C virus.The Journal of experimental medicine · 2005Article
- Wide range of quasispecies diversity during primary hepatitis C virus infection.Journal of virology · 2005Article
- Accurate representation of the hepatitis C virus quasispecies in 5.2-kilobase amplicons.Journal of clinical microbiology · 2004Article
- Long-term persistence of infection in chimpanzees inoculated with an infectious hepatitis C virus clone is associated with a decrease in the viral amino acid substitution rate and low levels of heterogeneity.Journal of virology · 2004Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
The putative envelope 2 (E2) gene of hepatitis C virus (HCV) contains a highly variable region referred to as hypervariable region 1 (HVR1). We hypothesized that this genetic variability is driven by immune selection pressure, rather than representing the accumulation of random mutations in a region with relatively little functional constraint. To test this hypothesis, we examined the E2 sequence of a human inoculum that was passaged through eight chimpanzees, which appear to have a replicative rate (opportunity for chance mutation) similar to that of humans. Acute-phase plasma samples from a human (the inoculum) and six of eight serially infected chimpanzees were studied. For each, 33 cloned cDNAs were examined by a combined heteroduplex-single-stranded conformational polymorphism assay to assess quasispecies complexity and optimize selection of clones with unique gel shift patterns (clonotypes) for sequencing. The sequence diversity of HCV was significantly lower in the chimpanzees than in the humans, and during eight serial passages there was no change in the sequence of the majority clonotype from each animal examined. Similarly, the rates of protein sequence altering (nonsynonymous) substitution were lower in the chimpanzees than in the humans. These findings demonstrate that nonsynonymous mutations indicate selection pressure rather than being an incidental result of HCV replication.
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