ArticleEnvironmental health perspectives2000
Strain differences in vaginal responses to the xenoestrogen bisphenol A.
Article in Environmental health perspectives, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 94 citations in OpenAlex.
- Genetic variation in sensitivity to estrogens and breast cancer risk.Mammalian genome : official journal of the International Mammalian Genome Society · 2018Review
- Article
- Effects of Low-Dose Developmental Bisphenol A Exposure on Metabolic Parameters and Gene Expression in Male and Female Fischer 344 Rat Offspring.Environmental health perspectives · 2017Article
- Low-dose exposure to bisphenol A in combination with fructose increases expression of genes regulating angiogenesis and vascular tone in juvenile Fischer 344 rat cardiac tissue.Upsala journal of medical sciences · 2017Article
- A review of the carcinogenic potential of bisphenol A.Reproductive toxicology (Elmsford, N.Y.) · 2016Review
- Strain-specific induction of endometrial periglandular fibrosis in mice exposed during adulthood to the endocrine disrupting chemical bisphenol A.Reproductive toxicology (Elmsford, N.Y.) · 2015Article
- Dose-dependent effects of the antiprogestin, RU486, on sexual behavior of naturally cycling Fischer rats.Behavioural brain research · 2015Article
- Mouse strain does not influence the overall effects of bisphenol a-induced toxicity in adult antral follicles.Biology of reproduction · 2013Article
- Sex specific impact of perinatal bisphenol A (BPA) exposure over a range of orally administered doses on rat hypothalamic sexual differentiation.Neurotoxicology · 2013Article
- Strain specific induction of pyometra and differences in immune responsiveness in mice exposed to 17α-ethinyl estradiol or the endocrine disrupting chemical bisphenol A.Reproductive toxicology (Elmsford, N.Y.) · 2012Article
- Bisphenol-A impairs memory and reduces dendritic spine density in adult male rats.Behavioral neuroscience · 2012Article
- Estrogenic environmental chemicals and drugs: mechanisms for effects on the developing male urogenital system.The Journal of steroid biochemistry and molecular biology · 2011Review
- Effects of bisphenol A on adipokine release from human adipose tissue: Implications for the metabolic syndrome.Molecular and cellular endocrinology · 2009Review
- Perinatal bisphenol A exposure increases estrogen sensitivity of the mammary gland in diverse mouse strains.Environmental health perspectives · 2007Article
- In vivo imaging of activated estrogen receptors in utero by estrogens and bisphenol A.Environmental health perspectives · 2004Article
- Xenoestrogen-induced ERK-1 and ERK-2 activation via multiple membrane-initiated signaling pathways.Environmental health perspectives · 2004Article
- Natural variability and the influence of concurrent control values on the detection and interpretation of low-dose or weak endocrine toxicities.Environmental health perspectives · 2004Article
- The intact immature rodent uterotrophic bioassay: possible effects on assay sensitivity of vomeronasal signals from male rodents and strain differences.Environmental health perspectives · 2003Article
- Increasing the sensitivity of the rodent uterotrophic assay to estrogens, with particular reference to bisphenol A.Environmental health perspectives · 2001Review
- Environmentally relevant xenoestrogen tissue concentrations correlated to biological responses in mice.Environmental health perspectives · 2000Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Bisphenol A (BPA) is the monomer component of polycarbonate plastics and epoxy resins; human exposure derives from leachate in foodstuffs packaged in certain plastics or from epoxy-based dental appliances. BPA stimulates prolactin secretion in Fischer 344 (F344) rats but not in Sprague-Dawley (S-D) rats. The present studies were performed to determine if another classic estrogen target tissue, the rat vagina, responds to BPA in a strain-specific manner. In F344 rats BPA increased DNA synthesis in vaginal epithelium with a median effective dose (ED(50)) of 37.5 mg/kg body weight; DNA synthesis was not stimulated in S-D rats by any dose tested. Clearance of (3)H-BPA from blood followed the same time course in both strains of rats, with a half-life of 90 min. Scatchard analysis of [(3)H]estradiol binding showed no strain differences in concentration or affinity of the vaginal estrogen receptor. BPA increased the level of mRNA for the immediate early gene, c-fos, with similar dose-response curves in both rat strains. Thus, F344 and S-D rats exhibit differences in sensitivity to BPA at the level of cell proliferation in the vaginal epithelium. However, metabolic clearance of BPA and the early events that lead to the proliferative response, receptor-ligand interaction and induction of immediate early genes, show no strain differences. These observations suggest that differences in intermediate effects must account for the difference in sensitivity of the proliferative response to the xenoestrogen. Furthermore, these results point to the need for caution in choosing a suitable end point and animal model when seeking to test the estrogenic effects of xenobiotics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.