ArticleMolecular and cellular biochemistry1999
Dexamethasone makes the gastric mucosa susceptible to ulceration by inhibiting prostaglandin synthetase and peroxidase--two important gastroprotective enzymes.
Article in Molecular and cellular biochemistry, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 54 citations in OpenAlex.
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- Clinicopathologic and gastrointestinal effects of administration of prednisone, prednisone with omeprazole, or prednisone with probiotics to dogs: A double-blind randomized trial.Journal of veterinary internal medicine · 2023Article
- Glucocorticoid regulation of cancer development and progression.Frontiers in endocrinology · 2023Review
- Dexamethasone sensitizes to ferroptosis by glucocorticoid receptor-induced dipeptidase-1 expression and glutathione depletion.Science advances · 2022Article
- Potential Adverse Effects of Dexamethasone Therapy on COVID-19 Patients: Review and Recommendations.Infectious diseases and therapy · 2021Review
- Technical note: fluorescein as an indicator of enteric mucosal barrier function in preruminant lambs.Journal of animal science · 2020Article
- Clinical, clinicopathologic, and gastrointestinal changes from administration of clopidogrel, prednisone, or combination in healthy dogs: A double-blind randomized trial.Journal of veterinary internal medicine · 2019Article
- Clinical, clinicopathologic, and gastrointestinal changes from aspirin, prednisone, or combination treatment in healthy research dogs: A double-blind randomized trial.Journal of veterinary internal medicine · 2019Article
- The prevalence of endoscopic gastric mucosal damage in patients with rheumatoid arthritis.PloS one · 2018Article
- Immunosuppressive agents are associated with peptic ulcer bleeding.Experimental and therapeutic medicine · 2017Article
- Article
- Inhibitory effects of a β-dunnione compound MB12662 on gastric secretion and ulcers.Laboratory animal research · 2013Article
- Article
- Glucocorticoids are Gastroprotective under Physiologic Conditions.Therapeutic advances in chronic disease · 2011Article
- Influence of proton pump inhibitors on dexamethasone-induced gastric mucosal damage in rats.Indian journal of pharmaceutical sciences · 2011Article
- Nonsteroidal Anti-Inflammatory Drug-Induced Gastroduodenal Bleeding: Risk Factors and Prevention Strategies.Pharmaceuticals (Basel, Switzerland) · 2010Review
- Comparative study of proton pump inhibitors on dexamethasone plus pylorus ligation induced ulcer model in rats.Indian journal of pharmaceutical sciences · 2010Article
- Gastric mucosal injury in systemic lupus erythematosus patients receiving pulse methylprednisolone therapy.British journal of clinical pharmacology · 2009Article
- Role of the serum and glucocorticoid inducible kinase SGK1 in glucocorticoid stimulation of gastric acid secretion.Pflugers Archiv : European journal of physiology · 2007Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The plausible mechanism by which dexamethasone makes the gastric mucosa susceptible to ulceration has been studied. As acid aggravates ulcer, the role of dexamethasone on acid secretion was first investigated. Dexamethasone stimulates both basal and drug (mercaptomethylimidazole)-induced gastric acid secretion by 100 and 50% respectively in male Wister rats 24 h after intramuscular administration at the dose of 1 mg/kg body wt. This stimulated acid secretion is 93% blocked by cimetidine indicating increased liberation of histamine in the process. Pretreatment of dexamethasone before 24 h produces ulcer in 30% of the pylorus- ligated rats and aggravates the ulcer index by 82% in both pylorus and esophagus ligated rats. The incidence of ulceration in the latter cases is also increased by 25%. As mucosal prostaglandin synthetase and peroxidase play an important role in gastroprotection through biosynthesis of prostaglandin and by scavenging endogenous H2O2 respectively, the effect of dexamethasone on the activities of these gastroprotective enzymes were studied. Prostaglandin synthetase and peroxidase activities of the mucosa are significantly inhibited by 87 and 83% respectively by 24-h pretreatment with dexamethasone. The results indicate that dexamethasone makes the mucosa prone to ulceration by inhibiting the activity of prostaglandin synthetase to block the gastroprotective action of prostaglandin and also by inhibiting the peroxidase, thereby elevating the endogenous H2O2 level to generate more reactive hydroxyl radical responsible for the mucosal damage.
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