ReviewJournal of mammary gland biology and neoplasia1999
Integrin function in breast carcinoma progression.
Review in Journal of mammary gland biology and neoplasia, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 58 citations in OpenAlex.
- Article
- Fertility-Associated Polymorphism within BovineAnimals : an open access journal from MDPI · 2021Article
- Novel Long Noncoding RNA 005620 Induces Epirubicin Resistance in Triple-Negative Breast Cancer by Regulating ITGB1 Expression.Frontiers in oncology · 2021Article
- Carbonic Anhydrase IX (CAIX), Cancer, and Radiation Responsiveness.Metabolites · 2018Review
- Penfluridol: An Antipsychotic Agent Suppresses Metastatic Tumor Growth in Triple-Negative Breast Cancer by Inhibiting Integrin Signaling Axis.Cancer research · 2016Article
- Up-regulation of integrin α6β4 expression by mitogens involved in dairy cow mammary development.In vitro cellular & developmental biology. Animal · 2015Article
- CDK11p58 inhibits ERα-positive breast cancer invasion by targeting integrin β3 via the repression of ERα signaling.BMC cancer · 2014Article
- NF-κB regulates radioresistance mediated by β1-integrin in three-dimensional culture of breast cancer cells.Cancer research · 2013Article
- Integrin signaling in mammary epithelial cells and breast cancer.ISRN oncology · 2012Article
- β1 integrin mediates an alternative survival pathway in breast cancer cells resistant to lapatinib.Breast cancer research : BCR · 2011Article
- β1-integrins signaling and mammary tumor progression in transgenic mouse models: implications for human breast cancer.Breast cancer research : BCR · 2011Review
- The Leu33Pro polymorphism in the ITGB3 gene does not modify BRCA1/2-associated breast or ovarian cancer risks: results from a multicenter study among 15,542 BRCA1 and BRCA2 mutation carriers.Breast cancer research and treatment · 2010Article
- Dual FGF-2 and intergrin alpha5beta1 signaling mediate GRAF-induced RhoA inactivation in a model of breast cancer dormancy.Cancer microenvironment : official journal of the International Cancer Microenvironment Society · 2009Article
- Article
- Alpha6beta4 integrin crosslinking induces EGFR clustering and promotes EGF-mediated Rho activation in breast cancer.Journal of experimental & clinical cancer research : CR · 2009Article
- Evidence for a role of tumor-derived laminin-511 in the metastatic progression of breast cancer.The American journal of pathology · 2007Article
- The emerging picture of the mouse mammary stem cell.Stem cell reviews · 2007Review
- Beta1 integrin inhibitory antibody induces apoptosis of breast cancer cells, inhibits growth, and distinguishes malignant from normal phenotype in three dimensional cultures and in vivo.Cancer research · 2006Article
- Involvement of insulin receptor substrate 2 in mammary tumor metastasis.Molecular and cellular biology · 2004Article
- Integrins in mammary gland development and differentiation of mammary epithelium.Journal of mammary gland biology and neoplasia · 2003Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The differentiation and function of mammary epithelial cells is dependent upon the combined action of growth factor/hormone receptors and integrin receptors, which act in concert to control the signals required for normal cell function. It is now becoming clear that integrin receptors also contribute to carcinoma cell behavior and that alterations in expression and function during transformation have a large impact on breast carcinoma progression. The focus of this review is to discuss integrin-dependent functions that can be manipulated as targets for the therapeutic intervention of breast cancer. A combination of correlative and mechanistic studies have contributed to the identification of specific integrin receptors, namely alpha2beta1, alpha6beta1, and alpha6beta4, implicated in breast carcinoma progression. Although this field is still emerging and much remains to be learned, potential integrin-dependent signaling targets have been identified.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.