ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2000
Organization of ionotropic glutamate receptors at dendrodendritic synapses in the rat olfactory bulb.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 88 citations in OpenAlex.
- Memantine fails to facilitate partial cigarette deprivation in smokers--no role of Memantine in the treatment of nicotine dependency?Journal of neural transmission (Vienna, Austria : 1996) · 2007Trial
- Signaling mechanisms underlying activity-dependent integration of adult-born neurons in the mouse olfactory bulb.Genesis (New York, N.Y. : 2000) · 2024Review
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- Dystroglycan Mediates Clustering of Essential GABAergic Components in Cerebellar Purkinje Cells.Frontiers in molecular neuroscience · 2020Article
- FAM49B, a novel regulator of mitochondrial function and integrity that suppresses tumor metastasis.Oncogene · 2018Article
- High-Resolution Quantitative Immunogold Analysis of Membrane Receptors at Retinal Ribbon Synapses.Journal of visualized experiments : JoVE · 2016Article
- The organization of AMPA receptor subunits at the postsynaptic membrane.Hippocampus · 2015Article
- Differential regulation of neurexin at glutamatergic and GABAergic synapses.Frontiers in cellular neuroscience · 2013Article
- Immunogold electron microscopic evidence of differential regulation of GluN1, GluN2A, and GluN2B, NMDA-type glutamate receptor subunits in rat hippocampal CA1 synapses during benzodiazepine withdrawal.The Journal of comparative neurology · 2010Article
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- Biophysical model for gamma rhythms in the olfactory bulb via subthreshold oscillations.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Subunit- and pathway-specific localization of NMDA receptors and scaffolding proteins at ganglion cell synapses in rat retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Increased AMPA receptor GluR1 subunit incorporation in rat hippocampal CA1 synapses during benzodiazepine withdrawal.The Journal of comparative neurology · 2008Article
- Glutamatergic transmission and plasticity between olfactory bulb mitral cells.The Journal of physiology · 2008Article
- Pharmacological analysis of ionotropic glutamate receptor function in neuronal circuits of the zebrafish olfactory bulb.PloS one · 2008Article
- Synaptic integration of adult-generated olfactory bulb granule cells: basal axodendritic centrifugal input precedes apical dendrodendritic local circuits.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Profilin2 contributes to synaptic vesicle exocytosis, neuronal excitability, and novelty-seeking behavior.The EMBO journal · 2007Article
- Multiple modes of synaptic excitation of olfactory bulb granule cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Distinct perisynaptic and synaptic localization of NMDA and AMPA receptors on ganglion cells in rat retina.The Journal of comparative neurology · 2006Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dendrodendritic synapses between mitral (or tufted) and granule cells of the olfactory bulb play a major role in the processes of odor discrimination and olfactory learning. Release of glutamate at these synapses activates postsynaptic receptors on the dendritic spines of granule cells, as well as presynaptic NMDA receptors in the mitral cell membrane. However, immunocytochemical studies have failed to demonstrate the presence of ionotropic glutamate receptors in granule cell dendrites. By using a postembedding immunogold procedure, we describe here the precise organization of neurotransmitter receptors at dendrodendritic synapses. We show that there is a selective localization of glutamate and GABA receptors at asymmetric and symmetric synaptic junctions, respectively. In addition, we demonstrate that NMDA and AMPA receptors are clustered at postsynaptic specializations on granule cell spines and that they are extensively colocalized. Conversely, glutamate receptors do not appear to be concentrated in clusters on mitral cell dendrites, suggesting that the presynaptic effects of glutamate are mediated by a small complement of extrasynaptic receptors. By analyzing the subsynaptic distribution of the NR1 and GluR2/3 subunits, we show that they are distributed along the entire extent of the postsynaptic specialization, indicating that both NMDA and AMPA receptors are available for dendrodendritic signaling between mitral and granule cells. These results indicate that the principles recently found to underlie the organization of glutamate receptors at axospinous synapses also apply to dendrodendritic synapses.
Indexed as
Identifiers
10704494PMC6772496W1535585371What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.