ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2000
Effects of neurotrophins on cortical plasticity: same or different?
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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Who cites it
32 citing papers in PubMed, 79 citations in OpenAlex.
- Role of BDNF in form-deprivation myopia progression in guinea pigs.Frontiers in immunology · 2026Article
- Brain Vitalization Gymnastics Improved Cognitive Function Marked by Increased BDNF, Decreased Serum Interleukin-6 and Decreased S-100β Expression among Elderly in West Denpasar Primary Health Clinic.Open access Macedonian journal of medical sciences · 2019Article
- Neuronal plasticity and neurotrophic factors in drug responses.Molecular psychiatry · 2017Article
- Differential effects of BDNF and neurotrophin 4 (NT4) on endocytic sorting of TrkB receptors.Journal of neurochemistry · 2016Article
- Experience-dependent DNA methylation regulates plasticity in the developing visual cortex.Nature neuroscience · 2015Article
- The bacterial protein toxin, cytotoxic necrotizing factor 1 (CNF1) provides long-term survival in a murine glioma model.BMC cancer · 2014Article
- Article
- Brain-derived neurotrophic factor (BDNF) reverses the effects of rapid eye movement sleep deprivation (REMSD) on developmentally regulated, long-term potentiation (LTP) in visual cortex slices.Neuroscience letters · 2012Article
- IGF-1 restores visual cortex plasticity in adult life by reducing local GABA levels.Neural plasticity · 2012Article
- Reducing intracortical inhibition in the adult visual cortex promotes ocular dominance plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Experimental and clinical evidence of neuroprotection by nerve growth factor eye drops: Implications for glaucoma.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- The role of neurotrophins in the seasonal-like growth of the avian song control system.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Molecular mechanisms of experience-dependent plasticity in visual cortex.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2009Review
- Visual deprivation decreases somatic GAD65 puncta number on layer 2/3 pyramidal neurons in mouse visual cortex.Neural plasticity · 2009Article
- Synaptic mechanisms for plasticity in neocortex.Annual review of neuroscience · 2009Review
- BDNF level in the rat prefrontal cortex increases following chronic but not acute treatment with duloxetine, a dual acting inhibitor of noradrenaline and serotonin re-uptake.Cellular and molecular neurobiology · 2008Article
- TrkB kinase is required for recovery, but not loss, of cortical responses following monocular deprivation.Nature neuroscience · 2008Article
- Insulin-like growth factor 1 (IGF-1) mediates the effects of enriched environment (EE) on visual cortical development.PloS one · 2007Article
- Transient synaptic silencing of developing striate cortex has persistent effects on visual function and plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- What is the biological significance of BDNF mRNA targeting in the dendrites? Clues from epilepsy and cortical development.Molecular neurobiology · 2006Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neurotrophins are important regulators of visual cortical plasticity. It is still unclear, however, whether they play similar or different roles and which are their effects on the electrical activity of cortical neurons in vivo. We therefore compared the effects of all neurotrophins, nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-4 (NT-4), and neurotrophin-3 (NT-3) on visual cortical plasticity and on cell spontaneous and visually evoked activity. Rats were monocularly deprived for 1 week at the peak of the critical period, and neurotrophins were infused intracortically. The main finding is that, with the exception of NT-3, all neurotrophins affect the outcome of monocular deprivation, but there are clear differences in their mechanisms of action. In particular, NT-4 and NGF counteract monocular deprivation effects without causing detectable alterations either in spontaneous or visually evoked neuronal activity. BDNF is less effective on ocular dominance plasticity and, in addition, strongly affects spontaneous and visually evoked activity in cortical neurons.
Indexed as
Identifiers
10704490PMC6772512W2145687320What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.