ArticleThe Journal of experimental medicine2000
The role of peptides in T cell alloreactivity is determined by self-major histocompatibility complex molecules.
Article in The Journal of experimental medicine, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 77 citations in OpenAlex.
- The Abundance of α-Chain-Centric TCRs in the Mouse Repertoire of Primarily Activated Effectors and Reactivated Memory T Cells.Computational and structural biotechnology journal · 2026Article
- TGF-β2 Reduces the Cell-Mediated Immunogenicity of Equine MHC-Mismatched Bone Marrow-Derived Mesenchymal Stem Cells Without Altering Immunomodulatory Properties.Frontiers in cell and developmental biology · 2021Article
- A "hotspot" for autoimmune T cells in type 1 diabetes.The Journal of clinical investigation · 2016Article
- What Is Direct Allorecognition?Current transplantation reports · 2016Review
- Identities of P2 and P3 Residues of H-2Kb-Bound Peptides Determine Mouse Ly49C Recognition.PloS one · 2015Article
- A similarity in peptide cross-reactivity between alloantigen- and nominal antigen-induced CD8+ T cell responses in vitro.Immunogenetics · 2013Article
- Concise review: immunologic lessons from solid organ transplantation for stem cell-based therapies.Stem cells translational medicine · 2013Review
- Individual MHCI-Restricted T-Cell Receptors are Characterized by a Unique Peptide Recognition Signature.Frontiers in immunology · 2013Article
- Cross-presentation by dendritic cells.Nature reviews. Immunology · 2012Review
- A computational pipeline to generate MHC binding motifs.Immunome research · 2011Article
- Alloreactivity is limited by the endogenous peptide repertoire.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Thymic selection stifles TCR reactivity with the main chain structure of MHC and forces interactions with the peptide side chains.Molecular immunology · 2008Review
- Cytotoxic herpes simplex type 2-specific, DQ0602-restricted CD4 T+-cell clones show alloreactivity to DQ0601.Immunology · 2006Article
- Zinc in pharmacological doses suppresses allogeneic reaction without affecting the antigenic response.Bone marrow transplantation · 2004Article
- The complementary roles of deletion and regulation in transplantation tolerance.Nature reviews. Immunology · 2003Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
By analyzing T cell responses against foreign major histocompatibility complex (MHC) molecules loaded with peptide libraries and defined self- and viral peptides, we demonstrate a profound influence of self-MHC molecules on the repertoire of alloreactive T cells: the closer the foreign MHC molecule is related to the T cell's MHC, the higher is the proportion of peptide-specific, alloreactive ("allorestricted") T cells versus T cells recognizing the foreign MHC molecule without regard to the peptide in the groove. Thus, the peptide repertoire of alloreactive T cells must be influenced by self-MHC molecules during positive or negative thymic selection or peripheral survival, much like the repertoire of the self-restricted T cells. In consequence, allorestricted, peptide-specific T cells (that are of interest for clinical applications) are easier to obtain if T cells and target cells express related MHC molecules.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.