ArticleThe Journal of cell biology2000
Schwann cell myelination requires timely and precise targeting of P(0) protein.
Article in The Journal of cell biology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
28 citing papers in PubMed, 72 citations in OpenAlex.
- How Does Protein Zero Assemble Compact Myelin?Cells · 2020Article
- Enhanced axonal neuregulin-1 type-III signaling ameliorates neurophysiology and hypomyelination in a Charcot-Marie-Tooth type 1B mouse model.Human molecular genetics · 2019Article
- A nonsense mutation in myelin protein zero causes congenital hypomyelination neuropathy through altered P0 membrane targeting and gain of abnormal function.Human molecular genetics · 2019Article
- DHTKD1 Deficiency Causes Charcot-Marie-Tooth Disease in Mice.Molecular and cellular biology · 2018Article
- A dual role for Integrin α6β4 in modulating hereditary neuropathy with liability to pressure palsies.Journal of neurochemistry · 2018Article
- Article
- Neurotrophin-4 induces myelin protein zero expression in cultured Schwann cells via the TrkB/PI3K/Akt/mTORC1 pathway.Animal cells and systems · 2017Article
- Article
- MpzR98C arrests Schwann cell development in a mouse model of early-onset Charcot-Marie-Tooth disease type 1B.Brain : a journal of neurology · 2012Article
- MLCK regulates Schwann cell cytoskeletal organization, differentiation and myelination.Journal of cell science · 2011Article
- Renal collecting system growth and function depend upon embryonic γ1 laminin expression.Development (Cambridge, England) · 2011Article
- Interplay between LXR and Wnt/β-catenin signaling in the negative regulation of peripheral myelin genes by oxysterols.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- P0S63del impedes the arrival of wild-type P0 glycoprotein to myelin in CMT1B mice.Human molecular genetics · 2011Article
- P0 (protein zero) mutation S34C underlies instability of internodal myelin in S63C mice.The Journal of biological chemistry · 2010Article
- Cholesterol regulates the endoplasmic reticulum exit of the major membrane protein P0 required for peripheral myelin compaction.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- P0 protein is required for and can induce formation of schmidt-lantermann incisures in myelin internodes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Ablation of the UPR-mediator CHOP restores motor function and reduces demyelination in Charcot-Marie-Tooth 1B mice.Neuron · 2008Article
- Immune cells contribute to myelin degeneration and axonopathic changes in mice overexpressing proteolipid protein in oligodendrocytes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Different intracellular pathomechanisms produce diverse Myelin Protein Zero neuropathies in transgenic mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Evolution of a neuroprotective function of central nervous system myelin.The Journal of cell biology · 2006Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
This report investigated mechanisms responsible for failed Schwann cell myelination in mice that overexpress P(0) (P(0)(tg)), the major structural protein of PNS myelin. Quantitative ultrastructural immunocytochemistry established that P(0) protein was mistargeted to abaxonal, periaxonal, and mesaxon membranes in P(0)(tg) Schwann cells with arrested myelination. The extracellular leaflets of P(0)-containing mesaxon membranes were closely apposed with periodicities of compact myelin. The myelin-associated glycoprotein was appropriately sorted in the Golgi apparatus and targeted to periaxonal membranes. In adult mice, occasional Schwann cells myelinated axons possibly with the aid of endocytic removal of mistargeted P(0). These results indicate that P(0) gene multiplication causes P(0) mistargeting to mesaxon membranes, and through obligate P(0) homophilic adhesion, renders these dynamic membranes inert and halts myelination.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.