ArticleMediators of inflammation1999
Leguminous lectins as tools for studying the role of sugar residues in leukocyte recruitment.
Article in Mediators of inflammation, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 67 citations in OpenAlex.
- Plant lectins as potent Anti-coronaviruses, Anti-inflammatory, antinociceptive and antiulcer agents.Saudi journal of biological sciences · 2022Review
- ConA-Like Lectins: High Similarity Proteins as Models to Study Structure/Biological Activities Relationships.International journal of molecular sciences · 2018Review
- The leguminous lectin of Lonchocarpus araripensis promotes antinociception via mechanisms that include neuronal inhibition of Na(+) currents.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2016Article
- A novel N-acetyl-glucosamine lectin of Lonchocarpus araripensis attenuates acute cellular inflammation in mice.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2016Article
- Structural studies of an anti-inflammatory lectin from Canavalia boliviana seeds in complex with dimannosides.PloS one · 2014Article
- Purification, partial characterization and immobilization of a mannose-specific lectin from seeds of Dioclea lasiophylla mart.Molecules (Basel, Switzerland) · 2013Article
- Effects of Canavalia lectins on acute inflammation in sensitized and non-sensitized rats.Inflammation · 2013Article
- Molecular modeling of lectin-like protein from Acacia farnesiana reveals a possible anti-inflammatory mechanism in Carrageenan-induced inflammation.BioMed research international · 2013Article
- Antifungal activity of lectins against yeast of vaginal secretion.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2012Article
- Antinociceptive and anti-inflammatory effects of a lectin-like substance from Clitoria fairchildiana R. Howard seeds.Molecules (Basel, Switzerland) · 2012Article
- Molecular characterization and tandem mass spectrometry of the lectin extracted from the seeds of Dioclea sclerocarpa Ducke.Molecules (Basel, Switzerland) · 2011Article
- Crystallization and preliminary X-ray diffraction analysis of a galactose-specific lectin from the seeds of Butea monosperma.Acta crystallographica. Section F, Structural biology and crystallization communications · 2011Article
- An anti-inflammatory lectin from Luetzelburgia auriculata seeds inhibits adhesion and rolling of leukocytes and modulates histamine and PGE2 action in acute inflammation models.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2010Article
- Vasodilator effects of Diocleinae lectins from the Canavalia genus.Naunyn-Schmiedeberg's archives of pharmacology · 2009Article
- Antinociceptive activity and toxicology of the lectin from Canavalia boliviana seeds in mice.Naunyn-Schmiedeberg's archives of pharmacology · 2009Article
- Crystallization and preliminary X-ray diffraction analysis of the lectin from Canavalia boliviana Piper seeds.Acta crystallographica. Section F, Structural biology and crystallization communications · 2009Article
- Lectins from the Red Marine Algal Species Bryothamnion seaforthii and Bryothamnion triquetrum as Tools to Differentiate Human Colon Carcinoma Cells.Advances in pharmacological sciences · 2009Article
- Antinociceptive and anti-inflammatory effects of a mucin-binding agglutinin isolated from the red marine alga Hypnea cervicornis.Naunyn-Schmiedeberg's archives of pharmacology · 2008Article
- Isolation and characterization of the potential receptor for wheat germ agglutinin from human neutrophils.Glycoconjugate journal · 2006Article
- Modulation of acute inflammation by a chitin-binding lectin from Araucaria angustifolia seeds via mast cells.Naunyn-Schmiedeberg's archives of pharmacology · 2006Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The natural physiological ligands for selectins are oligosaccharides found in glycoprotein or glycolipid molecules in cell membranes. In order to study the role of sugar residues in the in vivo lectin anti-inflammatory effect, we tested three leguminous lectins with different carbohydrate binding affinities in the peritonitis and paw oedema models induced by carrageenin in rats. L. sericeus lectin was more anti-inflammatory than D. virgata lectin, the effects being reversed by their specific binding sugars (N-acetylglucosamine and alpha-methylmannoside, respectively). However, V. macrocarpa, a galactose-specific lectin, was not anti-inflammatory. The proposed anti-inflammatory activity of lectins could be due to a blockage of neutrophil-selectin carbohydrate ligands. Thus, according to the present data, we suggest an important role for N-acetylglucosamine residue as the major ligand for selectins on rat neutrophil membranes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.