Evidence map›Paper›PMID 10699087›Full record

ArticleThe Journal of physiology2000

ATP as a mediator of mammalian central CO2 chemoreception.

T Thomas, K M Spyer

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of physiology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 74 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Retrotrapezoid nucleus and parafacial respiratory group.Respiratory physiology & neurobiology · 2010
    Review
  13. ATP, glia and central respiratory control.Respiratory physiology & neurobiology · 2010
    Review
  14. Central respiratory chemoreception.The Journal of comparative neurology · 2010
    Review
  15. Chemosensory pathways in the brainstem controlling cardiorespiratory activity.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2009
    Review
  16. Article
  17. Article
  18. P2Y1 receptor modulation of the pre-Bötzinger complex inspiratory rhythm generating network in vitro.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007
    Article
  19. Review
  20. Release of ATP in the ventral medulla during hypoxia in rats: role in hypoxic ventilatory response.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

T ThomasAutonomic Neuroscience Institute, Department of Physiology, Royal Free and University College Medical School, Royal Free Campus, Rowland Hill Street, London NW3 2PF, UK.
K M Spyer
The Royal Free Hospital · GBUniversity College London · GB

Funding

Wellcome Trust
6 · The paper itself

Abstract

1. A role for P2 purinoceptors in the chemosensory response of respiratory neurones localised in the ventrolateral medulla to changes in arterial CO2 levels was investigated in the anaesthetised rat. Extracellular recordings were made from different classes of respiratory neurone and the effects of P2 receptor blockade on CO2-evoked changes in activity investigated. 2. Increasing inspired CO2 excited 85 % of inspiratory neurones in the pre-Botzinger complex. In all cases, CO2-evoked excitation was blocked by ionophoretic application of the P2 receptor antagonists suramin (0.02 M) and pyridoxal-phosphate-6-azophenyl-2',4'-disulphonic acid (PPADS; 100 microM), but not the adenosine receptor antagonist 8-phenyltheophylline (8-PT; 100 microM). Suramin and PPADS often reduced ongoing activity, and blocked the excitatory effects of ATP. Inspiratory neurones were also excited by the P2X receptor agonist alphabeta-methyleneATP, suggesting a specific role for P2X receptors. 3. Sixty-six per cent of pre-inspiratory neurones were also excited by CO2. This effect was reduced or abolished by prior application of P2 receptor antagonists. Although post-inspiratory and expiratory neurones were excited by increasing levels of CO2, and also by ionophoretically applied ATP, the CO2-evoked effects were unaffected by P2 receptor blockade. 4. We suggest that ATP, possibly acting via P2X purinoceptors localised within the ventral respiratory group, is involved in central chemoreception. Specifically, these distinctive CO2-P2X-mediated actions were observed only in inspiratory neurones (incrementing inspiratory neurones and pre-inspiratory neurones), which appear to have purinoceptors with pH sensitivity that can account for the actions of CO2 in modifying ventilatory activity.

Indexed as

Adenosine TriphosphateAnimalsCarbon DioxideChemoreceptor CellsDose-Response Relationship, DrugIontophoresisMaleMedulla OblongataMicroelectrodesNeuronsPurinergic P1 Receptor AntagonistsPurinergic P2 Receptor AgonistsPurinergic P2 Receptor AntagonistsPyridoxal PhosphateRatsRats, Sprague-Dawley8-phenyltheophyllineAdenosine Triphosphatealpha,beta-methyleneadenosine 5'-triphosphateCarbon DioxidePurinergic P1 Receptor AntagonistsPurinergic P2 Receptor AgonistsPurinergic P2 Receptor AntagonistsPyridoxal Phosphatepyridoxal phosphate-6-azophenyl-2',4'-disulfonic acidSuraminTheophylline

Identifiers

PMID10699087
PMCPMC2269817
OpenAlexW2007404429

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.