ArticleThe Journal of physiology2000
P2X purinoceptor-induced sensitization of ferret vagal mechanoreceptors in oesophageal inflammation.
Article in The Journal of physiology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 76 citations in OpenAlex.
- The Expression of F2RL1, P2RX2, P2RX3 and P2RY2 in the Esophagus of Patients with Gastroesophageal Reflux Disease and Their Relationship to Reflux Symptoms-A Pilot Study.Journal of clinical medicine · 2025Article
- Determinants of reflux perception in patients with non-erosive reflux disease who have reflux-related symptoms on potassium-competitive acid blocker therapy.Esophagus : official journal of the Japan Esophageal Society · 2022Article
- Pathophysiological Role of Purinergic P2X Receptors in Digestive System Diseases.Frontiers in physiology · 2021Review
- Neuroimmune Communication in the Kidney.JMA journal · 2020Review
- Neuroimmune interactions and kidney disease.Kidney research and clinical practice · 2019Review
- Bioelectronic Approaches to Control Neuroimmune Interactions in Acute Kidney Injury.Cold Spring Harbor perspectives in medicine · 2019Review
- Effects of esophageal acidification on esophageal reflexes controlling the upper esophageal sphincter.American journal of physiology. Gastrointestinal and liver physiology · 2019Article
- The Cholinergic Anti-Inflammatory Response and the Role of Macrophages in HIV-Induced Inflammation.International journal of molecular sciences · 2018Review
- Targeting neural reflex circuits in immunity to treat kidney disease.Nature reviews. Nephrology · 2017Review
- Neuroimmune Interactions in Inflammation and Acute Kidney Injury.Frontiers in immunology · 2017Review
- Protease-Activated Receptor-2 Up-Regulates Transient Receptor Potential Vanilloid 4 Function in Mouse Esophageal Keratinocyte.Digestive diseases and sciences · 2015Article
- Characterization of synapses in the rat subnucleus centralis of the nucleus tractus solitarius.Journal of neurophysiology · 2015Article
- Purinergic signalling in the gastrointestinal tract and related organs in health and disease.Purinergic signalling · 2014Review
- Gastroesophageal reflux disease: Update on inflammation and symptom perception.World journal of gastroenterology · 2013Review
- Esophageal sensation and esophageal hypersensitivity - overview from bench to bedside.Journal of neurogastroenterology and motility · 2010Article
- Altered expression of P2X3 in vagal and spinal afferents following esophagitis in rats.Histochemistry and cell biology · 2009Article
- Peripheral and central P2X receptor contributions to colon mechanosensitivity and hypersensitivity in the mouse.Gastroenterology · 2009Article
- Purinergic mechanosensory transduction and visceral pain.Molecular pain · 2009Review
- Deletion of P2X3 receptors blunts gastro-oesophageal sensation in mice.Neurogastroenterology and motility · 2009Article
- Purinergic P2X receptor activation induces emetic responses in ferrets and Suncus murinus (house musk shrews).British journal of pharmacology · 2007Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. Using an in vitro single unit recording technique we studied the changes in mechanical and chemical sensitivity of vagal afferent fibres in acute oesophagitis, with particular attention to inflammatory products such as purines. 2. Histologically verified oesophagitis was induced by oesophageal perfusion of 1 mg ml-1 pepsin in 150 mM HCl in anaesthetized ferrets for 30 min on two consecutive days. Controls were infused with 154 mM NaCl. 3. The number of action potentials evoked in oesophageal mucosal afferents by mucosal stroking with calibrated von Frey hairs (10-1000 mg) was stimulus dependent. In oesophagitis responsiveness was reduced across the range of stimuli compared with controls. 4. Topical application of the P2X purinoceptor agonist alphabeta-methylene ATP had no direct excitatory effect on afferents. In oesophagitis, but not in controls, there was a significant increase in responses to stroking with von Frey hairs during superfusion with alphabeta-methylene ATP (1 microM). 5. Mucosal afferents responded directly to one or more chemical stimuli: 26 % (5/19 afferents) responded in controls, and 47 % (7/15 afferents) in oesophagitis. There were no differences in responsiveness to bradykinin (1 microM), prostaglandin E2 (100 microM), 5-hydroxytryptamine (100 microM), capsaicin (1 mM) or hydrochloric acid (150 mM) between control and oesophagitis groups. 6. We conclude that a sensitizing effect of a P2X purinoceptor agonist on mechanosensory function is induced in oesophagitis. This effect is offset by a decrease in basal mechanosensitivity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.