ArticleThe Journal of physiology2000
Tyrosine phosphorylation modulates the osmosensitivity of volume-dependent taurine efflux from glial cells in the rat supraoptic nucleus.
Article in The Journal of physiology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Astroglial Regulation of Magnocellular Neuroendocrine Cell Activities in the Supraoptic Nucleus.Neurochemical research · 2021Review
- Volume-dependent osmolyte efflux from neural tissues: regulation by G-protein-coupled receptors.Journal of neurochemistry · 2008Review
- Inhibition of ERK and JNK decreases both osmosensitive taurine release and cell proliferation in glioma cells.Neurochemical research · 2007Article
- The activation pathway of the volume-sensitive organic osmolyte channel in Xenopus laevis oocytes expressing skate anion exchanger 1 (AE1).The Journal of membrane biology · 2005Article
- Insulin-like growth factor-1 inhibits adult supraoptic neurons via complementary modulation of mechanoreceptors and glycine receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Ca2+-mediated potentiation of the swelling-induced taurine efflux from HeLa cells: on the role of calmodulin and novel protein kinase C isoforms.The Journal of membrane biology · 2004Article
- Vasopressin-induced taurine efflux from rat pituicytes: a potential negative feedback for hormone secretion.The Journal of physiology · 2004Article
- Calcium modulates osmosensitive taurine efflux in HeLa cells.Neurochemical research · 2004Review
- Regulation of the cellular content of the organic osmolyte taurine in mammalian cells.Neurochemical research · 2004Review
- Rho family GTP binding proteins are involved in the regulatory volume decrease process in NIH3T3 mouse fibroblasts.The Journal of physiology · 2002Article
- Influence of protein tyrosine kinases on cell volume change-induced taurine release.Cerebellum (London, England) · 2002Review
- Taurine release in the developing and adult mouse hippocampus: involvement of cyclic guanosine monophosphate.Neurochemical research · 2002Article
- Osmosensitive release of neurotransmitter amino acids: relevance and mechanisms.Neurochemical research · 2002Review
- Osmoregulation of vasopressin secretion via activation of neurohypophysial nerve terminals glycine receptors by glial taurine.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Signaling events during swelling and regulatory volume decrease.Neurochemical research · 2000Review
- Pharmacological characterization of volume-sensitive, taurine permeable anion channels in rat supraoptic glial cells.British journal of pharmacology · 2000Article
- Tyrosine phosphorylation modulates the osmosensitivity of volume-dependent taurine efflux from glial cells in the rat supraoptic nucleus.The Journal of physiology · 2000Article
Corrections and comments
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4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. In the supraoptic nucleus, taurine, selectively released in an osmodependent manner by glial cells through volume-sensitive anion channels, is likely to inhibit neuronal activity as part of the osmoregulation of vasopressin release. We investigated the involvement of various kinases in the activation of taurine efflux by measuring [3H]taurine release from rat acutely isolated supraoptic nuclei. 2. The protein tyrosine kinase inhibitors genistein and tyrphostin B44 specifically reduced, but did not suppress, both the basal release of taurine and that evoked by a hypotonic stimulus. Inhibition of tyrosine phosphatase by orthovanadate had the opposite effect. 3. The tyrosine kinase and phosphatase inhibitors shifted the relationship between taurine release and medium osmolarity in opposite directions, suggesting that tyrosine phosphorylation modulates the osmosensitivity of taurine release, but is not necessary for its activation. 4. Genistein also increased the amplitude of the decay of the release observed during prolonged hypotonic stimulation. Potentiation of taurine release by tyrosine kinases could serve to maintain a high level of taurine release in spite of cell volume regulation. 5. Taurine release was unaffected by inhibitors and/or activators of PKA, PKC, MEK and Rho kinase. 6. Our results demonstrate a unique regulation by protein tyrosine kinase of the osmosensitivity of taurine efflux in supraoptic astrocytes. This points to the presence of specific volume-dependent anion channels in these cells, or to a specific activation mechanism or regulatory properties. This may relate to the particular role of the osmodependent release of taurine in this structure in the osmoregulation of neuronal activity.
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