ArticleJournal of clinical microbiology2000
Clonal and spontaneous origins of fluconazole resistance in Candida albicans.
Article in Journal of clinical microbiology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it, 118 citations in OpenAlex.
- Interventions for prevention and treatment of vulvovaginal candidiasis in women with HIV infection.The Cochrane database of systematic reviews · 2011Pooled it
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- Genotypic and Phenotypic Analyses of Two "Isogenic" Strains of the Human Fungal Pathogen Cryptococcus neoformans var. neoformans.Mycopathologia · 2019Article
- Analyses of the Global Multilocus Genotypes of the Human Pathogenic YeastFrontiers in microbiology · 2019Article
- Diversity and relationships among strains of culturable yeasts in agricultural soils in Cameroon.Scientific reports · 2018Article
- Absence of Azole or Echinocandin Resistance in Candida glabrata Isolates in India despite Background Prevalence of Strains with Defects in the DNA Mismatch Repair Pathway.Antimicrobial agents and chemotherapy · 2018Article
- Identification of uncommon oral yeasts from cancer patients by MALDI-TOF mass spectrometry.BMC infectious diseases · 2018Article
- Multilocus sequence analyses reveal extensive diversity and multiple origins of fluconazole resistance in Candida tropicalis from tropical China.Scientific reports · 2017Article
- Risk factors for Candida parapsilosis bloodstream infection in a neonatal intensive care unit: a case-control study.Italian journal of pediatrics · 2017Article
- Multidrug-Resistant Candida auris Misidentified as Candida haemulonii: Characterization by Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry and DNA Sequencing and Its Antifungal Susceptibility Profile Variability by Vitek 2, CLSI Broth Microdilution, and Etest Method.Journal of clinical microbiology · 2015Article
- Invasive mycosis due to species of Blastobotrys in immunocompromised patients with reduced susceptibility to antifungals.Journal of clinical microbiology · 2014Article
- Prevalent drug resistance among oral yeasts from asymptomatic patients in Hainan, China.Mycopathologia · 2014Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
The genotypes and susceptibilities to fluconazole of 78 strains of the human pathogenic yeast Candida albicans were compared. The strains comprised two sets of samples from Durham, N.C.: one from patients infected with the human immunodeficiency virus (HIV) and the other from healthy volunteers. For each strain, the MIC of fluconazole was determined by the standard National Committee for Clinical Laboratory Standards protocol. Genotypes were determined by PCR fingerprinting with five separate primers. The analysis revealed little evidence for genotypic clustering according to HIV status or body site. However, a small group of fluconazole-resistant strains isolated from patients infected with HIV formed a distinct cluster. In addition, two fluconazole-resistant strains were isolated from individuals who never took fluconazole, one from a patient infected with HIV and the other from a healthy person. The results suggest both clonal and spontaneous origins of fluconazole resistance in C. albicans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.