ArticleJournal of clinical microbiology2000
Evaluation of a capacitance method for direct antifungal susceptibility testing of yeasts in positive blood cultures.
Article in Journal of clinical microbiology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Performance evaluation of machine-assisted interpretation of Gram stains from positive blood cultures.Journal of clinical microbiology · 2024Article
- Exploration of anti-Malassezia potential of Nyctanthes arbor-tristis L. and their application to combat the infection caused by Mala s1 a novel allergen.BMC complementary and alternative medicine · 2016Article
- Growth inhibitory response and ultrastructural modification of oral-associated candidal reference strains (ATCC) by Piper betle L. extract.International journal of oral science · 2014Article
- Antifungal susceptibility and growth inhibitory response of oral Candida species to Brucea javanica Linn. extract.BMC complementary and alternative medicine · 2013Article
- Rapid identification of pathogens from positive blood cultures by multiplex polymerase chain reaction using the FilmArray system.Diagnostic microbiology and infectious disease · 2012Article
- Use of a suspension array for rapid identification of the varieties and genotypes of the Cryptococcus neoformans species complex.Journal of clinical microbiology · 2005Article
- Amplifier spurious input current components in electrode-electrolyte interface impedance measurements.Biomedical engineering online · 2005Article
- Rapid identification of yeasts commonly found in positive blood cultures by amplification of the internal transcribed spacer regions 1 and 2.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2003Article
- Use of turbidimetric growth curves for early determination of antifungal drug resistance of filamentous fungi.Journal of clinical microbiology · 2003Article
- Potato dextrose agar antifungal susceptibility testing for yeasts and molds: evaluation of phosphate effect on antifungal activity of CMT-3.Antimicrobial agents and chemotherapy · 2002Article
- Antifungal susceptibility testing: practical aspects and current challenges.Clinical microbiology reviews · 2001Review
- Rapid identification of yeasts in positive blood cultures by a multiplex PCR method.Journal of clinical microbiology · 2001Article
- Evaluation of Etest for direct antifungal susceptibility testing of yeasts in positive blood cultures.Journal of clinical microbiology · 2001Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The feasibility of using a capacitance method (CM) for direct antifungal susceptibility testing of yeasts in positive blood cultures was evaluated. The CM used the same test conditions as those recommended by the National Committee for Clinical Laboratory Standards. After direct inoculation of positive culture broths into module wells (Bactometer; bioMérieux, Inc., Hazelwood, Mo.), the end-point determination was made by monitoring the capacitance change in the culture broths with Bactometer. The MIC of amphotericin B was the lowest concentration at which yeast growth was completely inhibited, while the MICs of ketoconazole, flucytosine, and fluconazole were the concentrations at which a >/=80% reduction in capacitance change was observed. The MICs of the four drugs against each blood isolate obtained on subculture plates were also determined by the macrodilution method. For 51 positive blood cultures tested, the percent agreement (+/-2 log(2) dilutions) between the CM and the macrodilution method were as follows: amphotericin B (98%), ketoconazole (92%), flucytosine (84%), and fluconazole (96%). The CM was further used for breakpoint susceptibility testing of fluconazole (8 and 64 microg/ml) and flucytosine (4 and 32 microg/ml) against yeasts in positive blood cultures. After testing of 74 specimens by the CM, flucytosine and fluconazole produced one (1.4%) major error and two (2.8%) minor errors, respectively. All yeasts that displayed resistance to flucytosine or fluconazole were detected within 24 h after direct inoculation of the positive broths into Bactometer. The CM may be useful for the rapid detection of antifungal resistance in positive blood cultures containing yeasts.
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