ArticleThe EMBO journal2000
Hormone activation induces nucleosome positioning in vivo.
Article in The EMBO journal, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 71 citations in OpenAlex.
- Article
- Quantification of transcription factor-DNA binding affinity in a living cell.Nucleic acids research · 2016Article
- The polyglutamine-expanded androgen receptor has increased DNA binding and reduced transcriptional activity.Biochemistry and biophysics reports · 2015Article
- ICM Web: the interactive chromatin modeling web server.Nucleic acids research · 2010Article
- Highly compacted chromatin formed in vitro reflects the dynamics of transcription activation in vivo.Molecular cell · 2010Article
- Genome-wide mechanisms of nuclear receptor action.Trends in endocrinology and metabolism: TEM · 2010Review
- FoxA1 binding directs chromatin structure and the functional response of a glucocorticoid receptor-regulated promoter.Molecular and cellular biology · 2009Article
- Chromatin context dominates estrogen regulation of pS2 gene expression.Experimental cell research · 2008Article
- Spontaneous access to DNA target sites in folded chromatin fibers.Journal of molecular biology · 2008Article
- Independent and complementary methods for large-scale structural analysis of mammalian chromatin.Genome research · 2007Article
- Mechanism of histone H1-stimulated glucocorticoid receptor DNA binding in vivo.Molecular and cellular biology · 2007Article
- Human SWI/SNF generates abundant, structurally altered dinucleosomes on polynucleosomal templates.Molecular and cellular biology · 2005Article
- Rapid, solid-phase based automated analysis of chromatin structure and transcription factor occupancy in living eukaryotic cells.Nucleic acids research · 2005Article
- Chromatin-mediated restriction of nuclear factor 1/CTF binding in a repressed and hormone-activated promoter in vivo.Molecular and cellular biology · 2004Article
- In vivo interactions of the Acanthamoeba TBP gene promoter.Nucleic acids research · 2004Article
- Retinoic acid receptor alpha fusion to PML affects its transcriptional and chromatin-remodeling properties.Molecular and cellular biology · 2003Article
- Glucocorticoids: new mechanisms and future agents.Current allergy and asthma reports · 2003Review
- Nucleosomes are translationally positioned on the active allele and rotationally positioned on the inactive allele of the HPRT promoter.Molecular and cellular biology · 2001Article
- Enhancer activity of HS2 of the human beta-LCR is modulated by distance from the key nucleosome.Nucleic acids research · 2001Article
- Hormone-induced nucleosome positioning in the MMTV promoter is reversible.The EMBO journal · 2001Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mouse mammary tumor virus (MMTV) promoter is induced by glucocorticoid hormone. A robust hormone- and receptor-dependent activation could be reproduced in Xenopus laevis oocytes. The homogeneous response in this system allowed a detailed analysis of the transition in chromatin structure following hormone activation. This revealed two novel findings: hormone activation led to the establishment of specific translational positioning of nucleosomes despite the lack of significant positioning in the inactive state; and, in the active promoter, a subnucleosomal particle encompassing the glucocorticoid receptor (GR)-binding region was detected. The presence of only a single GR-binding site was sufficient for the structural transition to occur. Both basal promoter elements and ongoing transcription were dispensable. These data reveal a stepwise process in the transcriptional activation by glucocorticoid hormone.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.