ReviewEnvironmental health perspectives2000
Molecular epidemiology studies on occupational and environmental exposure to mutagens and carcinogens, 1997-1999.
Review in Environmental health perspectives, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 109 citations in OpenAlex.
- Molecular mechanisms of air pollution-induced carcinogenesis and the emerging role of microplastics.Human genomics · 2025Review
- The Relationship between Exposure to Airborne Particulate and DNA Adducts in Blood Cells in an Urban Population of Subjects with an Unhealthy Body Mass Index.International journal of environmental research and public health · 2022Article
- The formation of SCEs as an effect of occupational exposure to formaldehyde.Archives of toxicology · 2022Article
- Evaluation of Carcinogenic Polyaromatic Hydrocarbon Levels in Airborne Particulates Associated with Long-Term Exposure throughout the COVID-19 Pandemic in Makkah, Saudi Arabia.International journal of environmental research and public health · 2021Article
- Polymorphism of xenobiotic metabolizing gene and susceptibility of epithelial ovarian cancer with reference to organochlorine pesticides exposure.Experimental biology and medicine (Maywood, N.J.) · 2019Article
- Decreased global DNA hydroxymethylation in neural tube defects: Association with polycyclic aromatic hydrocarbons.Epigenetics · 2019Article
- A Review of Epidemiological Research on Adverse Neurological Effects of Exposure to Ambient Air Pollution.Frontiers in public health · 2016Review
- Detection of benzo[a]pyrene-guanine adducts in single-stranded DNA using the α-hemolysin nanopore.Nanotechnology · 2015Article
- Assessment of the deoxyribonucleic acid damage caused by occupational exposure to chemical compounds in Isfahan Polyacryl Company.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2014Article
- Lead exposure: a summary of global studies and the need for new studies from Saudi Arabia.Disease markers · 2014Review
- Anti-mutagenicity Effects of Vitamin E on Oncology and Non-oncology Hospital Nurses by Ames Assay.Journal of clinical and diagnostic research : JCDR · 2013Article
- Non-chemical stressors and cumulative risk assessment: an overview of current initiatives and potential air pollutant interactions.International journal of environmental research and public health · 2011Review
- Prenatal exposure to airborne polycyclic aromatic hydrocarbons and children's intelligence at 5 years of age in a prospective cohort study in Poland.Environmental health perspectives · 2010Article
- Monitoring genotoxicity among gasoline station attendants and traffic enforcers in the City of Manila using the micronucleus assay with exfoliated epithelial cells.Environmental monitoring and assessment · 2009Article
- Modulation of the effect of prenatal PAH exposure on PAH-DNA adducts in cord blood by plasma antioxidants.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2009Article
- Differential oxidative stress response in young children and the elderly following exposure to PM(2.5).Environmental health and preventive medicine · 2009Article
- Biomonitoring of complex occupational exposures to carcinogens: the case of sewage workers in Paris.BMC cancer · 2008Article
- Primary DNA damage and genetic polymorphisms for CYP1A1, EPHX and GSTM1 in workers at a graphite electrode manufacturing plant.BMC public health · 2007Article
- Cancer epidemiology: study designs and data analysis.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2007Review
- Chromosomal aberrations in lymphocytes of healthy subjects and risk of cancer.Environmental health perspectives · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Molecular epidemiology is a new and evolving area of research, combining laboratory measurement of internal dose, biologically effective dose, biologic effects, and influence of individual susceptibility with epidemiologic methodologies. Biomarkers evaluated were selected according to basic scheme: biomarkers of exposure--metabolites in urine, DNA adducts, protein adducts, and Comet assay parameters; biomarkers of effect--chromosomal aberrations, sister chromatid exchanges, micronuclei, mutations in the hypoxanthine-guanine phosphoribosyltransferase gene, and the activation of oncogenes coding for p53 or p21 proteins as measured on protein levels; biomarkers of susceptibility--genetic polymorphisms of genes CYP1A1, GSTM1, GSTT1, NAT2. DNA adducts measured by 32P-postlabeling are the biomarker of choice for the evaluation of exposure to polycyclic aromatic hydrocarbons. Protein adducts are useful as a biomarker for exposure to tobacco smoke (4-aminobiphenyl) or to smaller molecules such as acrylonitrile or 1,3-butadiene. Of the biomarkers of effect, the most common are cytogenetic end points. Epidemiologic studies support the use of chromosomal breakage as a relevant biomarker of cancer risk. The use of the Comet assay and methods analyzing oxidative DNA damage needs reliable validation for human biomonitoring. Until now there have not been sufficient data to interpret the relationship between genotypes, biomarkers of exposure, and biomarkers of effect for assessing the risk of human exposure to mutagens and carcinogens.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.