ArticleCancer letters2000
Effect of constant light on DMBA mammary tumorigenesis in rats.
Article in Cancer letters, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 45 citations in OpenAlex.
- Night shift work and breast cancer: from etiopathology to precision risk analysis.NPJ breast cancer · 2025Review
- Exposure to brominated flame retardantsFrontiers in endocrinology · 2024Article
- Circadian disruption promotes tumor growth by anabolic host metabolism; experimental evidence in a rat model.BMC cancer · 2017Article
- Analysis of DNA-damage response to ionizing radiation in serum-shock synchronized human fibroblasts.Cell biology and toxicology · 2017Article
- The Pathophysiologic Role of Disrupted Circadian and Neuroendocrine Rhythms in Breast Carcinogenesis.Endocrine reviews · 2016Review
- Sleep interruption associated with house staff work schedules alters circadian gene expression.Sleep medicine · 2015Article
- An energy-optimal approach for entrainment of uncertain circadian oscillators.Biophysical journal · 2014Article
- Clock genes: their role in colorectal cancer.World journal of gastroenterology · 2014Review
- Circadian disruption leads to loss of homeostasis and disease.Sleep disorders · 2011Article
- Light-at-night, circadian disruption and breast cancer: assessment of existing evidence.International journal of epidemiology · 2009Article
- Photolyase/cryptochrome blue-light photoreceptors use photon energy to repair DNA and reset the circadian clock.Oncogene · 2002Review
- Clock genes of Mammalian cells: practical implications in tissue culture.In vitro cellular & developmental biology. AnimalReview
- Breast cancer and circadian disruption from electric lighting in the modern world.CA: a cancer journal for cliniciansReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A study of light, and mammary tumorigenesis was conducted in rats. One-hundred female Sprague-Dawley rats were divided by weight into two groups. One group was exposed to constant light (LL) from 26 days of age, and the second group was exposed to 8 h light and 16 h dark per day (LD). Both groups received an 8 mg dose of a chemical carcinogen, dimethylben-zanthracene (DMBA) at 52 days of age. At 13 weeks post-DMBA, there were significantly fewer mammary tumors in the LL group compared with the LD group. Constant light was clearly demonstrated to have a profound effect on mammary tissue development. Although virgin, the majority of the LL rats (29/50) had gross evidence of lactation at 141 days of age. None of the LD rats (0/50) showed evidence of milk production. These results suggest that constant light not only substantially accelerated mammary gland development, but pushed development of the tissue past the stage normally observed in virgin animals (to the lactation stage).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.