ReviewMolecular pathology : MP1999
Regulation of E-cadherin: does hypoxia initiate the metastatic cascade?
Review in Molecular pathology : MP, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- Review
- Regulation of Transactivation at C-TAD Domain of HIF-1Oxidative medicine and cellular longevity · 2022Review
- 4.1N-Mediated Interactions and Functions in Nerve System and Cancer.Frontiers in molecular biosciences · 2021Review
- Induction of epithelial-mesenchymal transition (EMT) and Gli1 expression in head and neck squamous cell carcinoma (HNSCC) spheroid cultures.Bosnian journal of basic medical sciences · 2018Article
- Influence of acute hypoxia and radiation quality on cell survival.Journal of radiation research · 2013Article
- Correlation between T-cadherin gene expression and aberrant methylation of T-cadherin promoter in human colon carcinoma cells.Medical oncology (Northwood, London, England) · 2012Article
- Transcriptional down-regulation of Brca1 and E-cadherin by CtBP1 in breast cancer.Molecular carcinogenesis · 2012Article
- The mechanisms by which polyamines accelerate tumor spread.Journal of experimental & clinical cancer research : CR · 2011Review
- Inhibition of hypoxia-inducible carbonic anhydrase-IX enhances hexokinase II inhibitor-induced hepatocellular carcinoma cell apoptosis.Acta pharmacologica Sinica · 2011Article
- The lysyl oxidases LOX and LOXL2 are necessary and sufficient to repress E-cadherin in hypoxia: insights into cellular transformation processes mediated by HIF-1.The Journal of biological chemistry · 2010Article
- Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Transcriptional regulation of urokinase-type plasminogen activator receptor by hypoxia-inducible factor 1 is crucial for invasion of pancreatic and liver cancer.Neoplasia (New York, N.Y.) · 2009Article
- Angiopoietin-like 4 prevents metastasis through inhibition of vascular permeability and tumor cell motility and invasiveness.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Redox sensor CtBP mediates hypoxia-induced tumor cell migration.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Correlation of invasion and metastasis of cancer cells, and expression of the RAD21 gene in oral squamous cell carcinoma.Virchows Archiv : an international journal of pathology · 2006Article
- Effect of laparotomy and CO(2) pneumoperitoneum on tumor growth of human colon carcinoma and expression pattern of tumor-associated proteins in the SCID mouse.International journal of colorectal disease · 2003Article
- Hypoxia attenuates the expression of E-cadherin via up-regulation of SNAIL in ovarian carcinoma cells.The American journal of pathology · 2003Article
- Hypoxia/reoxygenation induction of monocyte chemoattractant protein-1 in melanoma cells: involvement of nuclear factor-kappaB, stimulatory protein-1 transcription factors and mitogen-activated protein kinase pathways.The Biochemical journal · 2002Article
- E-cadherin and loss of heterozygosity at chromosome 16 in breast carcinogenesis: different genetic pathways in ductal and lobular breast cancer?Breast cancer research : BCR · 2002Review
- Cell adhesion molecules. Sticky moments in the clinic.BMJ (Clinical research ed.) · 1999Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ability of tumours to metastasis is regarded as one of the hallmarks of malignancy. The process through which tumours evolve to achieve this has been termed the metastatic cascade. This cascade has been the subject of much investigation over many years. One of the vital events identified by these investigations is the reduction of adhesion between tumour cells facilitating invasion of the surrounding tissues and vascular channels, ultimately leading to the development of a distant metastasis. E-cadherin and its associated catenin complex have been identified as key molecules in cell adhesion. This review looks at the structure and interaction of the E-cadherin-catenin complex and the factors that appear to regulate E-cadherin expression and thus cell adhesion. From the data gathered, it has become possible to propose the hypothesis that the development of tumour hypoxia is the initiating factor that sets the tumour on the road to metastasis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.