ArticleGene therapy2000
Gene transfer into inflamed glomeruli using macrophages transfected with adenovirus.
Article in Gene therapy, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 34 citations in OpenAlex.
- Lipocalin-2 abrogates epithelial cell cycle arrest by PPARγ inhibition.Laboratory investigation; a journal of technical methods and pathology · 2018Article
- Different effects of global osteopontin and macrophage osteopontin in glomerular injury.American journal of physiology. Renal physiology · 2018Article
- Macrophage A2A Adenosine Receptors Are Essential to Protect from Progressive Kidney Injury.The American journal of pathology · 2016Article
- Dendritic cells and macrophages in kidney disease.Clinical and experimental nephrology · 2010Review
- Isolation and transduction of monocytes: promising vehicles for therapeutic arteriogenesis.Langenbeck's archives of surgery · 2006Article
- Engineered E. coli delivers therapeutic genes to the colonic mucosa.Gene therapy · 2005Article
- Inhibition of macrophage nuclear factor-kappaB leads to a dominant anti-inflammatory phenotype that attenuates glomerular inflammation in vivo.The American journal of pathology · 2005Article
- Macrophages from inflamed but not normal glomeruli are unresponsive to anti-inflammatory cytokines.The American journal of pathology · 2000Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In vivo gene transfer to sites of inflammatory disease provides a novel method both for studying the effects of cytokines and growth factors, and for therapeutic intervention. Macrophages play a pivotal role in the development and control of inflammation and are therefore logical cells to use for genetic modification and in vivo gene delivery. In this study we show that macrophages (both cell lines and primary cultures) can be transfected by recombinant adenoviruses expressing beta-galactosidase, that the macrophages become activated by the transfection process as determined by generation of nitric oxide and can be easily manipulated to localise to inflamed glomeruli after direct injection into the renal artery of rats with an experimentally induced glomerular inflammation caused by nephrotoxic nephritis. The injection of transfected macrophages reduces the severity of injury in this model of glomerulonephritis as shown by a reduction in the degree of albuminuria. This approach provides a favourable system for gene delivery in inflammatory disease and shows that both the functional properties of the transfected macrophage as well the transgene it is engineered to produce are relevant for in vivo gene transfer. Gene Therapy (2000) 7, 263-270.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.