ArticleProceedings of the National Academy of Sciences of the United States of America2000
Postexposure vaccination massively increases the prevalence of gamma-herpesvirus-specific CD8+ T cells but confers minimal survival advantage on CD4-deficient mice.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 46 citations in OpenAlex.
- Indirect CD4Journal of virology · 2024Article
- Insights into CD8 T Cell Activation and Exhaustion from a Mouse Gammaherpesvirus Model.Viral immunology · 2020Review
- Immune Control ofViral immunology · 2020Article
- ORF6 and ORF61 Expressing MVA Vaccines Impair Early but Not Late Latency in Murine Gammaherpesvirus MHV-68 Infection.Frontiers in immunology · 2019Article
- CD8+ T cell evasion mandates CD4+ T cell control of chronic gamma-herpesvirus infection.PLoS pathogens · 2017Article
- Promotion of a subdominant CD8 T cell response during murine gammaherpesvirus 68 infection in the absence of CD4 T cell help.Journal of virology · 2014Article
- Defining immune engagement thresholds for in vivo control of virus-driven lymphoproliferation.PLoS pathogens · 2014Article
- CD8(+) T cells from mice transnuclear for a TCR that recognizes a single H-2K(b)-restricted MHV68 epitope derived from gB-ORF8 help control infection.Cell reports · 2012Article
- Suppressive CD8+ T cells arise in the absence of CD4 help and compromise control of persistent virus.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Mononucleosis and antigen-driven T cell responses have different requirements for interleukin-2 signaling in murine gammaherpesvirus infection.Journal of virology · 2010Article
- CD4 T-cell help programs a change in CD8 T-cell function enabling effective long-term control of murine gammaherpesvirus 68: role of PD-1-PD-L1 interactions.Journal of virology · 2010Article
- CD4+ T cell help has an epitope-dependent impact on CD8+ T cell memory inflation during murine cytomegalovirus infection.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Cutting edge: IL-2 immune complexes as a therapy for persistent virus infection.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Recall responses by helpless memory CD8+ T cells are restricted by the up-regulation of PD-1.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Article
- The murine gammaherpesvirus-68 gp150 acts as an immunogenic decoy to limit virion neutralization.PloS one · 2007Article
- Characterization of the protective T-cell response generated in CD4-deficient mice by a live attenuated Mycobacterium tuberculosis vaccine.Immunology · 2007Article
- Gammaherpesvirus persistence alters key CD8 T-cell memory characteristics and enhances antiviral protection.Journal of virology · 2006Article
- Effective control of chronic gamma-herpesvirus infection by unconventional MHC Class Ia-independent CD8 T cells.PLoS pathogens · 2006Article
- An optimized CD8+ T-cell response controls productive and latent gammaherpesvirus infection.Journal of virology · 2005Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
Abstract
Mice that lack CD4(+) T cells remain clinically normal for more than 60 days after respiratory challenge with the murine gamma-herpesvirus 68 (gammaHV-68), then develop symptoms of a progressive wasting disease. The gammaHV-68-specific CD8(+) T cells that persist in these I-A(b-/-) mice are unable to prevent continued, but relatively low level, virus replication. Postexposure challenge with recombinant vaccinia viruses expressing gammaHV-68 lytic cycle epitopes massively increased the magnitude of the gammaHV-68-specific CD8(+) population detectable by staining with tetrameric complexes of MHC class I glycoprotein + peptide, or by interferon-gamma production subsequent to in vitro restimulation with peptide. The boosting effect was comparable for gammaHV-68-infected I-A(b-/-) and I-A(b+/+) mice within 7 days of challenge, and took more than 110 days to return to prevaccination levels in the I-A(b+/+) controls. Although the life-span of the I-A(b-/-) mice was significantly increased, there was no effect on long-term survival. A further boost with a recombinant influenza A virus failed to improve the situation. Onset of weight loss was associated with a decline in gammaHV-68-specific CD8(+) T cell numbers, though it is not clear whether this was a cause or an effect of the underlying pathology. Even very high levels of virus-specific CD8(+) T cells thus provide only transient protection against the uniformly lethal consequences of gammaHV-68 infection under conditions of CD4(+) T cell deficiency.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.