ArticleBritish journal of pharmacology2000
Sustained ethanol inhibition of native AMPA receptors on medial septum/diagonal band (MS/DB) neurons.
Article in British journal of pharmacology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 34 citations in OpenAlex.
- Deleterious effects of a low amount of ethanol on LTP-like plasticity in human cortex.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Trial
- Synaptic Effects Induced by Alcohol.Current topics in behavioral neurosciences · 2025Review
- Ethanol Induces Microglial Cell Death via the NOX/ROS/PARP/TRPM2 Signalling Pathway.Antioxidants (Basel, Switzerland) · 2020Article
- Ketamine normalizes binge drinking-induced defects in glutamatergic synaptic transmission and ethanol drinking behavior in female but not male mice.Neuropharmacology · 2019Article
- Role of GABAMolecular brain · 2017Review
- Synaptic targets: Chronic alcohol actions.Neuropharmacology · 2017Review
- Synaptic effects induced by alcohol.Current topics in behavioral neurosciences · 2013Review
- Respiratory depression in rats induced by alcohol and barbiturate and rescue by ampakine CX717.Journal of applied physiology (Bethesda, Md. : 1985) · 2012Article
- Perturbation of the glutamate-glutamine system in alcohol dependence and remission.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2011Article
- Glutamate plasticity in the drunken amygdala: the making of an anxious synapse.International review of neurobiology · 2010Review
- Effects of topiramate and other anti-glutamatergic drugs on the acute intoxicating actions of ethanol in mice: modulation by genetic strain and stress.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2009Article
- Role of major NMDA or AMPA receptor subunits in MK-801 potentiation of ethanol intoxication.Alcoholism, clinical and experimental research · 2008Article
- Glutamatergic substrates of drug addiction and alcoholism.Biochemical pharmacology · 2008Review
- A functional glutamatergic neurone network in the medial septum and diagonal band area.The Journal of physiology · 2005Article
- Therapeutic potential of positive AMPA modulators and their relationship to AMPA receptor subunits. A review of preclinical data.Psychopharmacology · 2005Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The direct impact of ethanol on native, non-NMDA glutamate receptors was examined in acutely isolated MS/DB neurons from rat. The impact of ethanol functional tolerance and physical dependence on non-NMDA receptor function was also determined. Non-NMDA receptors were defined pharmacologically as predominantly the AMPA subtype, because both AMPA- or kainate-activated currents were blocked by GYKI 52466, a selective AMPA receptor antagonist. The relative magnitude of potentiation of AMPA-activated currents by 10 or 100 microM cyclothiazide was consistent with recombinant AMPA flop-subtype receptors. Finally, the selective kainate receptor agonist, SYM 8021, induced little current in MS/DB neurons. AMPA receptor currents when activated by kainate were sensitive to ethanol, showing inhibition of approximately 5 - 50% when 10 - 300 mM ethanol and kainate were briefly co-applied (3 s). Ethanol (100 mM) also inhibited both the initial transient peak and sustained currents activated by AMPA. Inhibition was sustained during continuous ethanol superfusions of 5 min, suggesting a lack of acute tolerance to ethanol-induced AMPA receptor blockade. Rapid application of 3 - 3000 microM kainate activated concentration-dependent currents in MS/DB neurons from Control and Ethanol Dependent animals that were not significantly different. Also, direct ethanol inhibition (300 mM) of kainate-activated currents was not reduced by ethanol dependence, suggesting a lack of functional tolerance. These results suggest that native AMPA receptors on MS/DB neurons are inhibited by pharmacologically-relevant concentrations of ethanol. However, these receptors, unlike NMDA receptors, do not undergo adaptation with sustained ethanol exposure sufficient to induce physical dependence. British Journal of Pharmacology (2000) 129, 87 - 94
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.