ArticleBiophysical journal2000
High-resolution imaging of antibodies by tapping-mode atomic force microscopy: attractive and repulsive tip-sample interaction regimes.
Article in Biophysical journal, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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Who cites it
55 citing papers in PubMed.
- Surface Reconstruction in Hydrated Amphiphilic Block Copolymer Thin Films Probed by Fluid Cell Atomic Force Microscopy.Macromolecules · 2026Article
- Direct Visualization of Segment-Like Dynamics in Isolated Polymer Chains on Solid Surfaces.Journal of the American Chemical Society · 2026Article
- Angstrom-Scale Water Layer Structure on van der Waals Materials Probed by 3D Atomic Force Microscopy: From Acidic to Alkaline Aqueous Solutions.Langmuir : the ACS journal of surfaces and colloids · 2026Article
- Nano-Raman Spectroscopy Figure of Merit and Chemical Analysis of Contaminations in Single-Layer MoSeACS nano · 2025Article
- Bimodal Atomic Force Microscopy with a Torsional Eigenmode for Highly Accurate Imaging of Grain Orientation in Organic Thin Films.Nano letters · 2025Article
- Pen direct writing of multiplex-LFIA for detection of thiamphenicol and tylosin in milk.Mikrochimica acta · 2025Article
- In Operando Imaging Electrostatic-Driven Disassembly and Reassembly of Collagen Nanostructures.ACS nano · 2024Article
- Atomic force microscopy-mediated mechanobiological profiling of complex human tissues.Biomaterials · 2023Review
- Scalable Synthesis of Carbon Nanomembranes from Amorphous Molecular Layers.ACS applied materials & interfaces · 2023Article
- Substrate-Selective Adhesion of Metal Nanoparticles to Graphene Devices.The journal of physical chemistry letters · 2023Article
- Simulations of Subnanometer Scale Image Contrast in Atomic Force Microscopy of Self-Assembled Monolayers in Water.Chemical & biomedical imaging · 2023Article
- Article
- 3D Generation of Multipurpose Atomic Force Microscopy Tips.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Tools shaping drug discovery and development.Biophysics reviews · 2022Review
- Atomic Force Microscopy (AFM) on Biopolymers and Hydrogels for Biotechnological Applications-Possibilities and Limits.Polymers · 2022Review
- Improved localization precision via restricting confined biomolecule stochastic motion in single-molecule localization microscopy.Nanophotonics (Berlin, Germany) · 2022Article
- Hydration Dynamics and the Future of Small-Amplitude AFM Imaging in Air.Molecules (Basel, Switzerland) · 2021Article
- Capturing transient antibody conformations with DNA origami epitopes.Nature communications · 2020Article
- Protein Quantification and Imaging by Surface-Enhanced Raman Spectroscopy and Similarity Analysis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Article
- Super-resolution imaging reveals the nanoscale organization of metabotropic glutamate receptors at presynaptic active zones.Science advances · 2020Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A force microscope operated with an amplitude modulation feedback (usually known as tapping-mode atomic force microscope) has two tip-sample interaction regimes, attractive and repulsive. We have studied the performance of those regimes to imaging single antibody molecules. The attractive interaction regime allows determination of the basic morphologies of the antibodies on the support. More importantly, this regime is able to resolve the characteristic Y-shaped domain structure of antibodies and the hinge region between domains. Imaging in the repulsive interaction regime is associated with the irreversible deformation of the molecules. This causes a significant loss in resolution and contrast. Two major physical differences distinguish the repulsive interaction regime from the attractive interaction regime: the existence of tip-sample contact and the strength of the forces involved.
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