ArticleBiophysical journal2000
Calcium currents in hair cells isolated from semicircular canals of the frog.
Article in Biophysical journal, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 71 citations in OpenAlex.
- Inhibition of cancerous properties of triple-negative MDA-MB-436 cells by targeting the KJournal of physiology and biochemistry · 2025Article
- Multiple Calcium Channel Types with Unique Expression Patterns Mediate Retinal Signaling at Bipolar Cell Ribbon Synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Cation Permeability of Voltage-Gated Hair Cell CaInternational journal of molecular sciences · 2022Article
- Simultaneous Dual Recordings From Vestibular Hair Cells and Their Calyx Afferents Demonstrate Multiple Modes of Transmission at These Specialized Endings.Frontiers in neurology · 2022Review
- Voltage-Gated Calcium Channels: Key Players in Sensory Coding in the Retina and the Inner Ear.Physiological reviews · 2018Review
- AMPA receptor-mediated rapid EPSCs in vestibular calyx afferents.Journal of neurophysiology · 2017Article
- A model of signal processing at the isolated hair cell of the frog semicircular canal.Journal of computational neuroscience · 2017Article
- Confirming a Role for α9nAChRs and SK Potassium Channels in Type II Hair Cells of the Turtle Posterior Crista.Frontiers in cellular neuroscience · 2017Article
- Nimodipine in otolaryngology: from past evidence to clinical perspectives.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2015Review
- Sensory transduction at the frog semicircular canal: how hair cell membrane potential controls junctional transmission.Frontiers in cellular neuroscience · 2015Article
- Hair cell-type dependent expression of basolateral ion channels shapes response dynamics in the frog utricle.Frontiers in cellular neuroscience · 2015Article
- Exocytotic machineries of vestibular type I and cochlear ribbon synapses display similar intrinsic otoferlin-dependent Ca2+ sensitivity but a different coupling to Ca2+ channels.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Patch-clamp recordings from lateral line neuromast hair cells of the living zebrafish.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
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- A pressure-polishing set-up to fabricate patch pipettes that seal on virtually any membrane, yielding low access resistance and efficient intracellular perfusion.European biophysics journal : EBJ · 2011Article
- FMRFamide-like peptides (FLPs) enhance voltage-gated calcium currents to elicit muscle contraction in the human parasite Schistosoma mansoni.PLoS neglected tropical diseases · 2010Article
- Isolation and possible role of fast and slow potassium current components in hair cells dissociated from frog crista ampullaris.Pflugers Archiv : European journal of physiology · 2009Article
- Molecular identity and functional properties of a novel T-type Ca2+ channel cloned from the sensory epithelia of the mouse inner ear.Journal of neurophysiology · 2008Article
- Biophysical properties of CaV1.3 calcium channels in gerbil inner hair cells.The Journal of physiology · 2008Article
- Development and regeneration of hair cells share common functional features.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
L-type and R-type Ca(2+) currents were detected in frog semicircular canal hair cells. The former was noninactivating and nifedipine-sensitive (5 microM); the latter, partially inactivated, was resistant to omega-conotoxin GVIA (5 microM), omega-conotoxin MVIIC (5 microM), and omega-agatoxin IVA (0.4 microM), but was sensitive to mibefradil (10 microM). Both currents were sensitive to Ni(2+) and Cd(2+) (>10 microM). In some cells the L-type current amplitude increased almost twofold upon repetitive stimulation, whereas the R-type current remained unaffected. Eventually, run-down occurred for both currents, but was prevented by the protease inhibitor calpastatin. The R-type current peak component ran down first, without changing its plateau, suggesting that two channel types generate the R-type current. This peak component appeared at -40 mV, reached a maximal value at -30 mV, and became undetectable for voltages > or =0 mV, suggestive of a novel transient current: its inactivation was indeed reversibly removed when Ba(2+) was the charge carrier. The L-type current and the R-type current plateau were appreciable at -60 mV and peaked at -20 mV: the former current did not reverse for voltages up to +60 mV, the latter reversed between +30 and +60 mV due to an outward Cs(+) current flowing through the same Ca(2+) channel. The physiological role of these currents on hair cell function is discussed.
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