ArticleImmunology2000
Demonstration that platelet-activating factor is capable of activating mast cells and inducing a chemotactic response.
Article in Immunology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 60 citations in OpenAlex.
- Targeting the Platelet-Activating Factor Receptor (PAF-R): Antithrombotic and Anti-Atherosclerotic Nutrients.Nutrients · 2022Review
- Effect of Platelet-Activating Factor on Barrier Function of ARPE-19 Cells.Drug design, development and therapy · 2020Article
- Chinese Society of Allergy Guidelines for Diagnosis and Treatment of Allergic Rhinitis.Allergy, asthma & immunology research · 2018Review
- Mast cells are important regulator of acupoint sensitization via the secretion of tryptase, 5-hydroxytryptamine, and histamine.PloS one · 2018Article
- Understanding the connection between platelet-activating factor, a UV-induced lipid mediator of inflammation, immune suppression and skin cancer.Progress in lipid research · 2016Review
- Sphingosine-1-phosphate and other lipid mediators generated by mast cells as critical players in allergy and mast cell function.European journal of pharmacology · 2016Review
- UVB Generates Microvesicle Particle Release in Part Due to Platelet-activating Factor Signaling.Photochemistry and photobiology · 2016Article
- Induction of Mast Cell Accumulation by Tryptase via a Protease Activated Receptor-2 and ICAM-1 Dependent Mechanism.Mediators of inflammation · 2016Article
- Correlation of IL-18 with Tryptase in Atopic Asthma and Induction of Mast Cell Accumulation by IL-18.Mediators of inflammation · 2016Article
- Article
- An essential role for platelet-activating factor in activating mast cell migration following ultraviolet irradiation.Journal of leukocyte biology · 2014Article
- Investigation of the lower resistance meridian: speculation on the pathophysiological functions of acupuncture meridians.Evidence-based complementary and alternative medicine : eCAM · 2014Article
- Mast cells and basophils are essential for allergies: mechanisms of allergic inflammation and a proposed procedure for diagnosis.Acta pharmacologica Sinica · 2013Review
- A Novel Platelet-Activating Factor Receptor Antagonist Inhibits Choroidal Neovascularization and Subretinal Fibrosis.PloS one · 2013Article
- Mast cell chemotaxis - chemoattractants and signaling pathways.Frontiers in immunology · 2012Article
- Platelet-activating factor-induced NF-kappaB activation and IL-8 production in intestinal epithelial cells are Bcl10-dependent.Inflammatory bowel diseases · 2010Article
- Mast cell activation is characterized by upregulation of a functional anaphylatoxin C5a receptor.BMC immunology · 2008Article
- Platelet activating factor as a mediator and therapeutic approach in bronchial asthma.Inflammation · 2008Review
- Mast cells in rheumatoid arthritis.Clinical rheumatology · 2007Review
- Leukotriene B4, an activation product of mast cells, is a chemoattractant for their progenitors.The Journal of experimental medicine · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Platelet-activating factor (PAF) is generated in a variety of inflammatory conditions in which mast cells accumulate. However, little is known about the ability of PAF to influence mast cell function directly. In this study we examine the ability of PAF to activate mast cells and regulate mast cell chemotaxis. PAF was found to induce intracellular calcium mobilization and chemotactic responses in both murine and human mast cells. PAF induced transient increases in intracellular Ca2+ concentrations with a 50% effective dose of 1 nM and induced significant migratory responses at PAF concentrations of 1 nM to 1 microM in the human leukaemia mast cell line (HMC-1). Using signal transduction inhibitors, both PAF-induced calcium mobilization and migration of mast cells were shown to require activation of pertussis toxin-sensitive G proteins. PAF-induced calcium and chemotactic responses were cross-desensitized by C5a. Together, these data demonstrate that PAF is capable of activating distinct signalling pathways in mast cells associated with calcium mobilization and cell migration; and that PAF may thus contribute to the regulation of mast cell responses and hyperplasia at sites of inflammation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.