ArticleImmunology2000
Vgamma1+ gammadelta T cells play protective roles at an early phase of murine cytomegalovirus infection through production of interferon-gamma.
Article in Immunology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 59 citations in OpenAlex.
- Immunological Interactions Between Gammadelta T Cells and West Nile Virus in the Infected Host.Reviews in medical virology · 2026Review
- Mammary γδ T cells promote IL-17A-mediated immunity againstiScience · 2023Article
- Development and function of natural TCRFrontiers in immunology · 2022Review
- γδ T cells in tissue physiology and surveillance.Nature reviews. Immunology · 2021Review
- Role of γδ T cells in controlling viral infections with a focus on influenza virus: implications for designing novel therapeutic approaches.Virology journal · 2020Review
- γδ T cells in cancer: a small population of lymphocytes with big implications.Clinical & translational immunology · 2019Review
- Connection between γδ T-cell- and Adenosine- Mediated Immune Regulation in the Pathogenesis of Experimental Autoimmune Uveitis.Critical reviews in immunology · 2018Review
- γδ T Cells Provide Protective Function in Highly Pathogenic Avian H5N1 Influenza A Virus Infection.Frontiers in immunology · 2018Article
- Article
- Functional Conversion and Dominance of γδ T Subset in Mouse Experimental Autoimmune Uveitis.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- γδ T Cell-Mediated Immunity to Cytomegalovirus Infection.Frontiers in immunology · 2017Review
- Aging influences the response of T cells to stimulation by the ellagitannin, oenothein B.International immunopharmacology · 2015Article
- γδ T cells confer protection against murine cytomegalovirus (MCMV).PLoS pathogens · 2015Article
- Control of murine cytomegalovirus infection by γδ T cells.PLoS pathogens · 2015Article
- Direct and Indirect Effects of Cytomegalovirus-Induced γδ T Cells after Kidney Transplantation.Frontiers in immunology · 2015Review
- Deciphering the role of DC subsets in MCMV infection to better understand immune protection against viral infections.Frontiers in microbiology · 2014Review
- Recognition of gut microbiota by NOD2 is essential for the homeostasis of intestinal intraepithelial lymphocytes.The Journal of experimental medicine · 2013Article
- Review
- Role of γδ T cells in West Nile virus-induced encephalitis: friend or foe?Journal of neuroimmunology · 2011Review
- Immunobiology of human cytomegalovirus: from bench to bedside.Clinical microbiology reviews · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cytomegalovirus (CMV) causes severe opportunistic infection in immunocompromised hosts. The importance of conventional alphabeta T cells in protection against CMV infection has been well documented. However, the role of the second T-cell population (which express the gammadelta T-cell receptor) in CMV infection is not known. In the present study, we analysed the function and protective role of gammadelta T cells in a murine cytomegalovirus (MCMV) infection model. After intraperitoneal infection with MCMV, the number of gammadelta T cells increased in the liver and peritoneal cavity from day 3, and reached a peak on day 5. The gammadelta T cells showed an activated T-cell phenotype and predominantly expressed Vgamma1, which is known to be expressed by heat-shock protein 65 (hsp 65)-specific gammadelta T cells. Analysis of cytokine expression demonstrated that the MCMV-induced gammadelta T cells expressed interferon-gamma (IFN-gamma) and tumour necrosis factor-alpha (TNF-alpha) but not interleukin-4 (IL-4), implying their participation in the cell-mediated immune response against MCMV. Depletion of gammadelta T cells by anti-T-cell receptor (TCR) gammadelta monoclonal antibody (mAb) treatment resulted in significant increase of virus titre and decrease of IFN-gamma in the liver on day 3 after MCMV infection, which further supports the importance of gammadelta T cells in early protection against infection. Finally, the MCMV-induced gammadelta T cells produced IFN-gamma in vitro in response to hsp 65. Our results suggest that gammadelta T cells participate in early protection against MCMV infection through recognition of hsp 65 and production of IFN-gamma.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.