ArticleClinical and experimental immunology2000
Neutrophil FcgammaRIIIb allelic polymorphism in anti-neutrophil cytoplasmic antibody (ANCA)-positive systemic vasculitis.
Article in Clinical and experimental immunology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 52 citations in OpenAlex.
- Pitfalls When Determining HNA-1 Genotypes and Finding Novel Alleles.International journal of molecular sciences · 2024Article
- ANCA-associated vasculitis in Caucasian and Hispanics of the Inland Empire of Southern California.Clinical rheumatology · 2022Article
- Advances in the genomics of ANCA-associated vasculitis-a view from East Asia.Genes and immunity · 2021Review
- Pathogenicity of Proteinase 3-Anti-Neutrophil Cytoplasmic Antibody in Granulomatosis With Polyangiitis: Implications as Biomarker and Future Therapies.Frontiers in immunology · 2021Review
- Glomerulonephritis in AKI: From Pathogenesis to Therapeutic Intervention.Frontiers in medicine · 2020Review
- Fcγ Receptor Heterogeneity in Leukocyte Functional Responses.Frontiers in immunology · 2017Review
- ANCA-associated vasculitis in Hispanic Americans: an unrecognized severity.Clinical rheumatology · 2015Article
- Genetics of ANCA-associated Vasculitides.Current rheumatology reports · 2014Review
- Targeting the Fc receptor in autoimmune disease.Expert opinion on therapeutic targets · 2014Review
- Contribution of Human FcγRs to Disease with Evidence from Human Polymorphisms and Transgenic Animal Studies.Frontiers in immunology · 2014Review
- Human FcR polymorphism and disease.Current topics in microbiology and immunology · 2014Review
- Article
- The biological significance of evolution in autoimmune phenomena.Autoimmune diseases · 2012Article
- Wegener's granulomatosis: a model of auto-antibodies in mucosal autoimmunity.Clinical immunology (Orlando, Fla.) · 2010Review
- The contribution of genetic variation and infection to the pathogenesis of ANCA-associated systemic vasculitis.Arthritis research & therapy · 2010Review
- Functional and clinical consequences of Fc receptor polymorphic and copy number variants.Clinical and experimental immunology · 2009Review
- Copy number variation in the human genome and its implication in autoimmunity.Clinical and experimental immunology · 2009Review
- Update on pathogenic mechanisms of systemic necrotizing vasculitis.Current rheumatology reports · 2008Review
- Copy number of FCGR3B, which is associated with systemic lupus erythematosus, correlates with protein expression and immune complex uptake.The Journal of experimental medicine · 2008Article
- Anti-neutrophil cytoplasmic (ANCA) and anti-glomerular basement membrane (GBM) autoantibodies in necrotizing and crescentic glomerulonephritis.Seminars in immunopathology · 2007Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neutrophils constitutively express FcgammaRIIa and FcgammaRIIIb receptors. Both receptors exhibit allelic variants which have different quantitative functional capacities: the biallelic FcgammaRIIa-R131 and -H131 alleles, and the neutrophil antigen (NA) NA1/NA2 alleles. ANCA activation of neutrophils requires ligation of FcgammaRIIa receptor, but recent data have shown that ANCA can also bind FcgammaRIIIb receptor. The aim of this study was to determine whether the FcgammaRIIIb polymorphism was a risk factor for the development of ANCA-associated systemic vasculitis, or the associated nephritis. FcgammaRIIIb receptor genotyping was determined by allele-specific polymerase chain reaction. Genomic DNA was extracted from 101 Caucasian patients with ANCA+ vasculitis (of whom 84 had renal disease) and 100 ethnically matched controls. Of the patients with ANCA+ systemic vasculitis, 71 had ANCA with specificity for proteinase 3 and 30 with specificity for myeloperoxidase (MPO). Overall no significant difference in genotype distribution or allele frequencies was found between patients and controls, or between patients with renal disease and controls. However, there was a trend for an increase in homozygosity for the NA1 allele in patients with a vasculitis and this was significant in patients who had anti-MPO antibodies. The FcgammaRIIIb receptor polymorphism is not a major factor predisposing to the development of ANCA+ systemic vasculitis or the associated nephritis. The over-representation of the FcgammaRIIIb homozygous NA1 allele in patients with anti-MPO antibodies may have implications for disease susceptibility.
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Registered trials
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