ArticleJournal of molecular neuroscience : MN
Activity-dependent interaction of the intracellular domain of rat trkA with intermediate filament proteins, the beta-6 proteasomal subunit, Ras-GRF1, and the p162 subunit of eIF3.
Article in Journal of molecular neuroscience : MN. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 43 citations in OpenAlex.
- Translational Control in Cancer.Cold Spring Harbor perspectives in biology · 2019Review
- RasGRF1 mediates brain-derived neurotrophic factor-induced axonal growth in primary cultured cortical neurons.Biochemistry and biophysics reports · 2019Article
- TrkB Regulates N-Methyl-D-Aspartate Receptor Signaling by Uncoupling and Recruiting the Brain-Specific Guanine Nucleotide Exchange Factor, RasGrf1.Journal of molecular neuroscience : MN · 2019Article
- Proteins directly interacting with mammalian 20S proteasomal subunits and ubiquitin-independent proteasomal degradation.Biomolecules · 2014Review
- A role for the tyrosine kinase ACK1 in neurotrophin signaling and neuronal extension and branching.Cell death & disease · 2013Article
- Eukaryotic translation initiation factor 3, subunit a, regulates the extracellular signal-regulated kinase pathway.Molecular and cellular biology · 2012Article
- Imprinted Rasgrf1 expression in neonatal mice affects olfactory learning and memory.Genes, brain, and behavior · 2011Article
- Article
- Identification of novel RasGRF1 interacting partners by large-scale proteomic analysis.Journal of molecular neuroscience : MN · 2009Article
- The Ras-GRF1 exchange factor coordinates activation of H-Ras and Rac1 to control neuronal morphology.Molecular biology of the cell · 2006Article
- Ras activation of a Rac1 exchange factor, Tiam1, mediates neurotrophin-3-induced Schwann cell migration.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Nesca, a novel adapter, translocates to the nuclear envelope and regulates neurotrophin-induced neurite outgrowth.The Journal of cell biology · 2004Article
- An intact intermediate filament network is required for collateral sprouting of small diameter nerve fibers.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- EIF3 p170, a mediator of mimosine effect on protein synthesis and cell cycle progression.Molecular biology of the cell · 2003Article
- Desmin cytoskeleton in healthy and failing heart.Heart failure reviews · 2000Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many responses to nerve growth factor (NGF) are regulated through the receptor tyrosine kinase trkA. To understand more fully the functions of trkA in NGF responsive cells, we have expressed the intracellular domain of rat trkA as a fusion protein with the yeast gal4 transcription factor, and used the fusion protein to probe rat and mouse cDNA libraries by the yeast two-hybrid system. We have identified a direct interaction between the intracellular domain of trkA and two members of the intermediate filament (IF) family of proteins, the guanine-nucleotide exchange protein Ras-GRF1, the p162 subunit of eIF3, and the beta-6 proteasome subunit. The interactions are dependent on an active trkA kinase, and RasGRF1, the beta-6 proteasomal subunit, and peripherin are directly phosphorylated by trkA. The interaction with trkA is not affected by mutations at either Tyr499 or Tyr794, the two major phosphotyrosine residues essential to the activation and receptor binding of Shc, FRS-2/SNT, and phospholipase Cgamma-1, and it is highly specific in vitro for trkA, with little or no binding observed with trkB and/or trkC. The results show that trkA may play a regulatory role in a variety of cellular functions in addition to neuritogenesis, including regulated protein degradation and transcriptional activation.
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