ArticleHuman immunology2000
HLA class II haplotype associations with inflammatory bowel disease in Jewish (Ashkenazi) and non-Jewish caucasian populations.
Article in Human immunology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 92 citations in OpenAlex.
- Shared CD4+ T cell receptor specificity groups in Crohn's disease and ulcerative colitis.JCI insight · 2026Article
- The shared circulating diagnostic biomarkers and molecular mechanisms of systemic lupus erythematosus and inflammatory bowel disease.Frontiers in immunology · 2024Article
- A human leukocyte antigen imputation study uncovers possible genetic interplay between gut inflammatory processes and autism spectrum disorders.Translational psychiatry · 2023Article
- Gastrointestinal Manifestations in Patients with Systemic Lupus Erythematosus.Open access rheumatology : research and reviews · 2022Review
- Prevalance of Celiac Disease in Patients with Inflammatory Bowel Disease in Turkish Population.Gastroenterology research and practice · 2019Article
- Immunogenetic biomarkers in inflammatory bowel diseases: role of the IBD3 region.World journal of gastroenterology · 2014Review
- Susceptibility to Crohn's disease is mediated by KIR2DL2/KIR2DL3 heterozygosity and the HLA-C ligand.Immunogenetics · 2009Article
- Defining the role of the MHC in autoimmunity: a review and pooled analysis.PLoS genetics · 2008Review
- Inflammatory bowel disease: genetic and epidemiologic considerations.World journal of gastroenterology · 2008Review
- TNFSF15 is an ethnic-specific IBD gene.Inflammatory bowel diseases · 2007Article
- Genetics of inflammatory bowel disease: current status and future directions.Canadian journal of gastroenterology = Journal canadien de gastroenterologie · 2006Review
- Genetics of inflammatory bowel disease: the role of the HLA complex.World journal of gastroenterology · 2006Review
- Current concept on the pathogenesis of inflammatory bowel disease-crosstalk between genetic and microbial factors: pathogenic bacteria and altered bacterial sensing or changes in mucosal integrity take "toll" ?World journal of gastroenterology · 2006Review
- Inflammatory bowel disease in Ashkenazi Jews: implications for familial colorectal cancer.Familial cancer · 2004Review
- Validation of the interleukin-10 knockout mouse model of colitis: antitumour necrosis factor-antibodies suppress the progression of colitis.Clinical and experimental immunology · 2003Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Ulcerative colitis (UC) and Crohn's disease (CD) are the clinical entities comprising idiopathic inflammatory bowel disease (IBD). Previous studies on the association of IBD and human leukocyte antigen (HLA) class II genes suggested a role for HLA in this disease. Here we present HLA class II (DRB1, DQB1, DQA1, DPB1) allele and haplotype distributions determined using the polymerase chain reaction and sequence-specific oligonucleotide probe methods. A total of 578 UC and CD Caucasian patients and controls from Jewish (Ashkenazi) and non-Jewish populations was examined. Our previously reported association of DR1-DQ5 with CD was attributable to DRB1*0103. A dramatic association with IBD and the highly unusual DRB1*0103-DQA1*0501-DQB1*0301 haplotype (OR = 6.6, p = 0.036) was found. The more common DR1 haplotype, DRB1*0103-DQA1*0101-DQB1*0501, was also associated with IBD (OR = 3.1, p = 0.014), a result suggesting that interaction between DR and DQ may determine the extent of disease risk. Our previously reported association of DR2 with UC was attributable to DRB1*1502 (OR = 2.6, p = 0.006). At the DPB1 locus, a significant association of DPB1*0401 with CD was observed for the combined populations (OR = 1.85, p = 0.007). These observations indicate that some class II alleles and haplotypes confer susceptibility to both UC and CD, implying common immunogenetic mechanisms of pathogenesis, while others confer risk to only one of these diseases, and illustrate the value of DNA HLA typing in disease susceptibility analyses.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.