ArticleProceedings of the National Academy of Sciences of the United States of America2000
Chip interacts with diverse homeodomain proteins and potentiates bicoid activity in vivo.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
41 citing papers in PubMed, 85 citations in OpenAlex.
- FlyPredictome: A structural atlas of predicted protein-protein interactions inbioRxiv : the preprint server for biology · 2026Article
- A Structure-Guided Kinase-Transcription Factor Interactome Atlas Reveals Docking Landscapes of the Kinome.bioRxiv : the preprint server for biology · 2025Article
- Planarian LDB and SSDP proteins scaffold transcriptional complexes for regeneration and patterning.Developmental biology · 2024Article
- Enhanced Protein-Protein Interaction Discovery via AlphaFold-Multimer.bioRxiv : the preprint server for biology · 2024Article
- Human ERG oncoprotein repressesProceedings of the National Academy of Sciences of the United States of America · 2023Article
- The LHX2-OTX2 transcriptional regulatory module controls retinal pigmented epithelium differentiation and underlies genetic risk for age-related macular degeneration.PLoS biology · 2023Article
- Mechanisms of Enhancer-Promoter Interactions in Higher Eukaryotes.International journal of molecular sciences · 2021Review
- Seeing is believing: the Bicoid protein reveals its path.Hereditas · 2018Article
- The LDB1 Complex Co-opts CTCF for Erythroid Lineage-Specific Long-Range Enhancer Interactions.Cell reports · 2017Article
- Enhancer biology and enhanceropathies.Nature structural & molecular biology · 2014Review
- Transcriptional activators and activation mechanisms.Protein & cell · 2011Review
- SSDP cofactors regulate neural patterning and differentiation of specific axonal projections.Developmental biology · 2011Article
- Regulation of LIM-domain-binding 1 protein expression by ubiquitination of Lys134.The Biochemical journal · 2010Article
- The genome-wide dynamics of the binding of Ldb1 complexes during erythroid differentiation.Genes & development · 2010Article
- The transcriptional co-factor Chip acts with LIM-homeodomain proteins to set the boundary of the eye field in Drosophila.Development (Cambridge, England) · 2010Article
- Lmo4 and Clim1 progressively delineate cortical projection neuron subtypes during development.Cerebral cortex (New York, N.Y. : 1991) · 2009Article
- Regulation of estrogen-dependent transcription by the LIM cofactors CLIM and RLIM in breast cancer.Cancer research · 2009Article
- Drosophila LIM-only is a positive regulator of transcription during thoracic bristle development.Genetics · 2008Article
- Review
- A positive role for NLI/Ldb1 in long-range beta-globin locus control region function.Molecular cell · 2007Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
The Drosophila protein Chip potentiates activation by several enhancers and is required for embryonic segmentation. Chip and its mammalian homologs interact with and promote dimerization of nuclear LIM proteins. No known Drosophila LIM proteins, however, are required for segmentation, nor for expression of most genes known to be regulated by Chip. Here we show that Chip also interacts with diverse homeodomain proteins using residues distinct from those that interact with LIM proteins, and that Chip potentiates activity of one of these homeodomain proteins in Drosophila embryos and in yeast. These and other observations help explain the roles of Chip in segmentation and suggest a model to explain how Chip potentiates activation by diverse enhancers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.