ArticleProceedings of the National Academy of Sciences of the United States of America2000
Light affects cAMP signaling and cell movement activity in Dictyostelium discoideum.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 34 citations in OpenAlex.
- Effect of Retinal on Dictyostelium Cells During Development.Genes to cells : devoted to molecular & cellular mechanisms · 2025Article
- Light Affects Host-Symbiont Dynamics in the Non-Photosynthetic Social Amoeba Symbiosis.Ecology and evolution · 2025Article
- ATP and glutamate coordinate contractions in the freshwater sponge Ephydatia muelleri.The Journal of experimental biology · 2025Article
- Article
- Photobehaviours guided by simple photoreceptor systems.Animal cognition · 2023Review
- Article
- Origins of eukaryotic excitability.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- Article
- Optical control of excitation waves in cardiac tissue.Nature photonics · 2015Article
- Light-Directed Migration ofSensors and actuators. A, Physical · 2012Article
- Evolution of phototaxis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2009Review
- High-throughput analysis of spatio-temporal dynamics in Dictyostelium.Genome biology · 2007Article
- The cyclase-associated protein CAP as regulator of cell polarity and cAMP signaling in Dictyostelium.Molecular biology of the cell · 2004Article
- Abnormalities of Endocytosis, Phagocytosis, and Development Process in Dictyostelium Cells That Over-Express Acanthamoeba castellanii Metacaspase Protein.Iranian journal of parasitologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The multicellular, slug stage of the slime mould Dictyostelium discoideum lacks specific sensory cells and organs but can nevertheless respond in a very sensitive manner to external stimuli such as temperature and light. Within the migrating slug, the behavior of up to 100,000 individual amoebae is coordinated by cAMP mediated cell-cell signaling and chemotaxis. We report here the striking result that light directly modulates the cAMP cell-cell signaling system. Light-induced secretion of cAMP from the slug tips decreased the period length of optical density waves and speeded up cell movement. A local effect of light on cAMP release within the slug tip could modulate cell movement within the slug and thus control its phototactic turning and orientation toward a light source.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.