ArticleProceedings of the National Academy of Sciences of the United States of America2000
Tyrosine phosphorylation of p62dok by p210bcr-abl inhibits RasGAP activity.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 63 citations in OpenAlex.
- A PTP1B-Cdk3 Signaling Axis Promotes Cell Cycle Progression of Human Glioblastoma Cells through an Rb-E2F Dependent Pathway.Molecular and cellular biology · 2023Article
- Recent advances in PTP1B signaling in metabolism and cancer.Bioscience reports · 2021Review
- Suppression of USP7 induces BCR-ABL degradation and chronic myelogenous leukemia cell apoptosis.Cell death & disease · 2021Article
- The non-genomic loss of function of tumor suppressors: an essential role in the pathogenesis of chronic myeloid leukemia chronic phase.BMC cancer · 2016Review
- Protein tyrosine phosphatases: structure, function, and implication in human disease.Methods in molecular biology (Clifton, N.J.) · 2013Review
- SRC Homology 2 Domain Binding Sites in Insulin, IGF-1 and FGF receptor mediated signaling networks reveal an extensive potential interactome.Cell communication and signaling : CCS · 2012Article
- PTP1B: a double agent in metabolism and oncogenesis.Trends in biochemical sciences · 2010Review
- Differential phosphoproteomics of fibroblast growth factor signaling: identification of Src family kinase-mediated phosphorylation events.Journal of proteome research · 2010Article
- Essential roles for Dok2 and RasGAP in CD200 receptor-mediated regulation of human myeloid cells.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Activation of Src by protein tyrosine phosphatase 1B Is required for ErbB2 transformation of human breast epithelial cells.Cancer research · 2009Article
- Quantitative time-resolved phosphoproteomic analysis of mast cell signaling.Journal of immunology (Baltimore, Md. : 1950) · 2007Article
- Dok-1 independently attenuates Ras/mitogen-activated protein kinase and Src/c-myc pathways to inhibit platelet-derived growth factor-induced mitogenesis.Molecular and cellular biology · 2006Article
- Dok-R mediates attenuation of epidermal growth factor-dependent mitogen-activated protein kinase and Akt activation through processive recruitment of c-Src and Csk.Molecular and cellular biology · 2005Article
- Overexpression of FAK promotes Ras activity through the formation of a FAK/p120RasGAP complex in malignant astrocytoma cells.Oncogene · 2004Article
- Role of NF-kappa B in cell survival and transcription of latent membrane protein 1-expressing or Epstein-Barr virus latency III-infected cells.Journal of virology · 2004Article
- Signals mediated by FcgammaRIIA suppress the growth of B-lineage acute lymphoblastic leukemia cells.Leukemia · 2002Article
- p62(dok), a negative regulator of Ras and mitogen-activated protein kinase (MAPK) activity, opposes leukemogenesis by p210(bcr-abl).The Journal of experimental medicine · 2001Article
- Phosphoinositide 3-kinase-dependent membrane recruitment of p62(dok) is essential for its negative effect on mitogen-activated protein (MAP) kinase activation.The Journal of experimental medicine · 2001Article
- Inhibition of the motility and growth of B16F10 mouse melanoma cells by dominant negative mutants of Dok-1.Molecular and cellular biology · 2001Article
- Molecular biology of chronic myeloid leukemia.International journal of hematology · 2001Review
Corrections and comments
- Erratum issued
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The t(9;22) chromosomal translocation is found in almost all patients with chronic myelogenous leukemia. The resultant Bcr-Abl fusion gene expresses a chimeric fusion protein p210(bcr-abl) with increased tyrosine kinase activity. Hematopoietic progenitors isolated from chronic myelogenous leukemia patients in the chronic phase contain constitutively tyrosine-phosphorylated p62(dok) protein. p62(dok) associates with the Ras GTPase-activating protein (RasGAP), but only when p62(dok) is tyrosine phosphorylated. Here we have investigated the interaction between p62(dok) and RasGAP and the consequences of p62(dok) tyrosine phosphorylation on the activity of RasGAP. We have found that p62(dok) is directly tyrosine phosphorylated by p210(bcr-abl), and the sites of phosphorylation are located in the C-terminal half of the p62(dok) molecule. We have identified five tyrosine residues that are involved in in vitro RasGAP binding and have found that tyrosine-phosphorylated p62(dok) inhibits RasGAP activity. Our results suggest that p210(bcr-abl) might lead to the activation of the Ras signaling pathway by inhibiting a key down-regulator of Ras signaling.
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