ArticleMolecular and cellular biology2000
Pocket protein-independent repression of urokinase-type plasminogen activator and plasminogen activator inhibitor 1 gene expression by E2F1.
Article in Molecular and cellular biology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 45 citations in OpenAlex.
- AP1 Transcription Factor in the Regulation of the Urokinase Plasminogen Activation System.Biomolecules · 2026Review
- Modeling Developmental and Tumorigenic Aspects of Trilateral Retinoblastoma via Human Embryonic Stem Cells.Stem cell reports · 2017Article
- Retinoblastoma tumor suppressor protein in pancreatic progenitors controls α- and β-cell fate.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Transforming growth factor-Beta and urokinase-type plasminogen activator: dangerous partners in tumorigenesis-implications in skin cancer.ISRN dermatology · 2013Article
- Skip Regulates TGF- β 1-Induced Extracellular Matrix Degrading Proteases Expression in Human PC-3 Prostate Cancer Cells.Prostate cancer · 2013Article
- Article
- Rb/E2F1 regulates the innate immune receptor Toll-like receptor 3 in epithelial cells.Molecular and cellular biology · 2012Article
- Article
- Curcumin Induces Downregulation of E2F4 Expression and Apoptotic Cell Death in HCT116 Human Colon Cancer Cells; Involvement of Reactive Oxygen Species.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2010Article
- Repression of transcriptional activity of C/EBPalpha by E2F-dimerization partner complexes.Molecular and cellular biology · 2010Article
- Article
- Regulation of plasminogen activator inhibitor-1 expression by tumor suppressor protein p53.The Journal of biological chemistry · 2008Article
- F-box protein Skp2: a novel transcriptional target of E2F.Oncogene · 2006Article
- Identification and modulation of a caveolae-dependent signal pathway that regulates plasminogen activator inhibitor-1 in insulin-resistant adipocytes.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Blocking of FGFR signaling inhibits breast cancer cell proliferation through downregulation of D-type cyclins.Oncogene · 2004Article
- Negative regulation of urokinase-type plasminogen activator production through FGF-2-mediated activation of phosphoinositide 3-kinase.Oncogene · 2002Article
- The identification of E2F1-specific target genes.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- E2F-1 represses transcription of the human telomerase reverse transcriptase gene.Nucleic acids research · 2001Article
- E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis.Genes & development · 2001Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Expression of genes of the plasminogen activator (PA) system declines at the G(0)/G(1)-S-phase boundary of the cell cycle. We found that overexpression of E2F1-3, which acts mainly in late G(1), inhibits promoter activity and endogenous expression of the urokinase-type PA (uPA) and PA inhibitor 1 (PAI-1) genes. This effect is dose dependent and conserved in evolution. Mutation analysis indicated that both the DNA-binding and transactivation domains of E2F1 are necessary for this regulation. Interestingly, an E2F1 mutant lacking the pRB-binding region strongly repressed the uPA and PAI-1 promoters. An E2F-mediated negative effect was also observed in pRB and p107/p130 knockout cell lines. This is the first report that E2F can act as a repressor independently of pocket proteins. Mutation of AP-1 elements in the uPA promoter abrogated E2F-mediated transcriptional inhibition, suggesting the involvement of AP-1 in this regulation. Results shown here identify E2F as an important component of transcriptional control of the PA system and thus provide new insights into mechanisms of cellular proliferation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.