ArticleNucleic acids research2000
Characterisation of the U83 and U84 small nucleolar RNAs: two novel 2'-O-ribose methylation guide RNAs that lack complementarities to ribosomal RNAs.
Article in Nucleic acids research, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- Small Nucleolar RNAs (snoRNAs) in Cancer: From Biogenesis to Clinical Potential.OncoTargets and therapy · 2026Review
- Structural basis of RNA conformational switching in the transcriptional regulator 7SK RNP.Molecular cell · 2022Article
- Effects of Cardiac Sympathetic Neurodegeneration and PPARBioMed research international · 2020Article
- Dual function of C/D box small nucleolar RNAs in rRNA modification and alternative pre-mRNA splicing.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Update on non-canonical microRNAs.Biomolecular concepts · 2014Review
- Processing of snoRNAs as a new source of regulatory non-coding RNAs: snoRNA fragments form a new class of functional RNAs.BioEssays : news and reviews in molecular, cellular and developmental biology · 2013Review
- Efficient oligonucleotide-mediated degradation of nuclear noncoding RNAs in mammalian cultured cells.RNA (New York, N.Y.) · 2009Article
- Evolution and comparative analysis of the MHC Class III inflammatory region.BMC genomics · 2006Article
- Identification of 13 novel human modification guide RNAs.Nucleic acids research · 2003Article
- Evidence for the role of PWCR1/HBII-85 C/D box small nucleolar RNAs in Prader-Willi syndrome.American journal of human genetics · 2002Article
- RNomics in Archaea reveals a further link between splicing of archaeal introns and rRNA processing.Nucleic acids research · 2002Article
- Small nucleolar RNAs: versatile trans-acting molecules of ancient evolutionary origin.Gene expression · 2002Review
- Box C/D RNA guides for the ribose methylation of archaeal tRNAs. The tRNATrp intron guides the formation of two ribose-methylated nucleosides in the mature tRNATrp.Nucleic acids research · 2001Article
- Small nucleolar RNA-guided post-transcriptional modification of cellular RNAs.The EMBO journal · 2001Review
- RNomics: an experimental approach that identifies 201 candidates for novel, small, non-messenger RNAs in mouse.The EMBO journal · 2001Article
- Identification of 10 novel snoRNA gene clusters from Arabidopsis thaliana.Nucleic acids research · 2001Article
- Imprinted expression of small nucleolar RNAs in brain: time for RNomics.Proceedings of the National Academy of Sciences of the United States of America · 2000Review
- Identification of brain-specific and imprinted small nucleolar RNA genes exhibiting an unusual genomic organization.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In eukaryotic cells, the site-specific 2'- O -ribose methylation of ribosomal RNAs (rRNAs) and the U6 spliceosomal small nuclear RNA (snRNA) is directed by small nucleolar RNAs (snoRNAs). The C and D box-containing 2'- O -methylation guide snoRNAs select the correct substrate nucleotide through formation of a long 10-21 bp interaction with the target rRNA and U6 snRNA sequences. Here, we report on the characterisation of two novel mammalian C/D box snoRNAs, called U83 and U84, that contain all the elements that are essential for accumulation and function of 2'- O -methylation guide snoRNAs. However, in contrast to all of the known 2'- O -methylation guide RNAs, the human, mouse and pig U83 and U84 snoRNAs feature no antisense elements complementary to rRNA or U6 snRNA sequences. The human U83 and U84 snoRNAs are not associated with maturing nucleolar pre-ribosomal particles, suggesting that they do not function in rRNA biogenesis. Since artificial substrate RNAs complementary to the evolutionarily conserved putative substrate recognition motifs of the U83 and U84 snoRNAs were correctly 2'- O -methylated in the nucleolus of mouse cells, we suggest that the new snoRNAs act as 2'- O -methylation guides for cellular RNAs other then rRNAs and the U6 snRNA.
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