ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2000
Activation of extracellular signal-regulated protein kinases is associated with a sensitized locomotor response to D(2) dopamine receptor stimulation in unilateral 6-hydroxydopamine-lesioned rats.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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Who cites it
22 citing papers in PubMed, 77 citations in OpenAlex.
- Rapid and sustained antidepressant effects of tubastatin A in a mouse model of depression.Scientific reports · 2025Article
- Genetic loss of the dopamine transporter significantly impacts behavioral and molecular responses to sub-chronic stress in mice.Frontiers in molecular neuroscience · 2024Article
- Nuclear ERK1/2 signaling potentiation enhances neuroprotection and cognition via Importinα1/KPNA2.EMBO molecular medicine · 2023Article
- Abnormalities of Dopamine DJournal of central nervous system disease · 2017Review
- mTORC2/rictor signaling disrupts dopamine-dependent behaviors via defects in striatal dopamine neurotransmission.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- BDNF-TrkB signaling in striatopallidal neurons controls inhibition of locomotor behavior.Nature communications · 2013Article
- Effects of the dopamine D2 allosteric modulator, PAOPA, on the expression of GRK2, arrestin-3, ERK1/2, and on receptor internalization.PloS one · 2013Article
- The role of the dopamine transporter in dopamine-induced DNA damage.Brain pathology (Zurich, Switzerland) · 2011Article
- Sex differences in the activity of signalling pathways and expression of G-protein-coupled receptor kinases in the neonatal ventral hippocampal lesion model of schizophrenia.The international journal of neuropsychopharmacology · 2011Article
- Nitrated alpha-synuclein induces the loss of dopaminergic neurons in the substantia nigra of rats.PloS one · 2010Article
- Neurochemical changes in the striatum of dyskinetic rats after administration of the cannabinoid agonist WIN55,212-2.Neurochemistry international · 2009Article
- A potential neuroanatomical dissociation of DARPP-32 in striatal ERK signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Review
- Neuroplasticity in brain reward circuitry following a history of ethanol dependence.The European journal of neuroscience · 2008Article
- Spatiotemporal pattern of striatal ERK1/2 phosphorylation in a rat model of L-DOPA-induced dyskinesia and the role of dopamine D1 receptors.Biological psychiatry · 2007Article
- Neonatal exposure to epidermal growth factor induces dopamine D2-like receptor supersensitivity in adult sensorimotor gating.Psychopharmacology · 2007Article
- Synthesis, protein levels, activity, and phosphorylation state of tyrosine hydroxylase in mesoaccumbens and nigrostriatal dopamine pathways of chronically food-restricted rats.Brain research · 2006Article
- Dopaminergic control of sleep-wake states.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Circadian phase-dependent modulation of cGMP-gated channels of cone photoreceptors by dopamine and D2 agonist.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Control of lactotrop proliferation by dopamine: essential role of signaling through D2 receptors and ERKs.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Impaired D2 dopamine receptor function in mice lacking type 5 adenylyl cyclase.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Evidence indicates that mitogen-activated protein kinase (MAPK) pathways play a crucial role in the neurobiology of the nervous system. In the present study, dopamine receptor-mediated regulation of extracellular signal-regulated kinases (ERKs) was examined in rats in which the nigrostriatal dopaminergic pathway was unilaterally lesioned by 6-hydroxydopamine (6-OHDA). Subcutaneous injections of the D(2) receptor agonist quinpirole significantly increased tyrosine-phosphorylated ERK1/2 in lesioned striatum, whereas the D(1) receptor agonist SKF38393 failed to activate ERKs. Quinpirole-induced phosphorylation of ERK1/2 was seen as early as 3 min and peaked at 15 min after the challenge. In parallel, striatal ERK kinase activity, measured by the in vitro kinase assay, was increased 2.5-fold on the lesioned side after the administration of quinpirole. Immunohistochemical examination of brain sections after quinpirole administration revealed significant increases in ERK1/2 immunostaining in perinuclear and intranuclear areas of striatal neurons. This increase was much more pronounced on the lesioned than the intact side. Furthermore, quinpirole-induced contralateral rotation was decreased by 48.7 and 50.7%, respectively, when the striatal ERK pathway was selectively inhibited by a single intrastriatal injection of the MAPK/ERK kinase inhibitor PD098059 or after a continuous 7 d intrastriatal infusion of ERK1/2 antisense oligodeoxynucleotide. The results demonstrate, for the first time, that the ERK signaling pathway is activated in denervated striatum in response to stimulation of D(2) dopamine receptors and that the resulting imbalance in striatal ERK activity contributes, at least in part, to neuronal plasticity that underlies D(2) dopamine receptor-mediated contralateral rotation in unilateral 6-OHDA denervated rats.
Indexed as
Identifiers
10684886PMC6772914W1902740936What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.