ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2000
Tachykinin-related peptide and GABA-mediated presynaptic inhibition of crayfish photoreceptors.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 52 citations in OpenAlex.
- Immunocytochemical Localization of Enzymes Involved in Dopamine, Serotonin, and Acetylcholine Synthesis in the Optic Neuropils and Neuroendocrine System of Eyestalks ofFrontiers in neuroanatomy · 2022Article
- Multifaceted Mass Spectrometric Investigation of Neuropeptide Changes in Atlantic Blue Crab, Callinectes sapidus, in Response to Low pH Stress.Journal of proteome research · 2019Article
- Tachykinins: Neuropeptides That Are Ancient, Diverse, Widespread and Functionally Pleiotropic.Frontiers in neuroscience · 2019Review
- Article
- Parasitoid Jewel Wasp Mounts Multipronged Neurochemical Attack to Hijack a Host Brain.Molecular & cellular proteomics : MCP · 2019Article
- Relative Quantitation of Neuropeptides at Multiple Developmental Stages of the American Lobster Using N, N-Dimethyl Leucine Isobaric Tandem Mass Tags.ACS chemical neuroscience · 2018Article
- Substrates for Neuronal Cotransmission With Neuropeptides and Small Molecule Neurotransmitters inFrontiers in cellular neuroscience · 2018Review
- Invaginating Presynaptic Terminals in Neuromuscular Junctions, Photoreceptor Terminals, and Other Synapses of Animals.Neuromolecular medicine · 2017Review
- Crustacean neuropeptides.Cellular and molecular life sciences : CMLS · 2010Review
- Metabolic stress responses in Drosophila are modulated by brain neurosecretory cells that produce multiple neuropeptides.PloS one · 2010Article
- Neuropeptide signaling near and far: how localized and timed is the action of neuropeptides in brain circuits?Invertebrate neuroscience : IN · 2009Review
- Presynaptic peptidergic modulation of olfactory receptor neurons in Drosophila.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Neural organization of first optic neuropils in the littoral crab Hemigrapsus oregonensis and the semiterrestrial species Chasmagnathus granulatus.The Journal of comparative neurology · 2009Article
- Brain architecture in the terrestrial hermit crab Coenobita clypeatus (Anomura, Coenobitidae), a crustacean with a good aerial sense of smell.BMC neuroscience · 2008Article
- Organization of optic lobes that support motion detection in a semiterrestrial crab.The Journal of comparative neurology · 2005Article
- Retrograde signaling from the brain to the retina modulates the termination of the light response in Drosophila.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Off-axis illumination elicits lateral inhibition at the primary visual synapse in crustacea and insects. The evidence suggests that the inhibitory action is presynaptic (i.e., on the photoreceptor terminal) and that the amacrine neurons of the lamina ganglionaris (the first synaptic layer) may be part of the inhibitory pathway. The neurotransmitters and the synaptic mechanisms are unknown. We show by immunocytochemistry that GABA and a tachykinin-related peptide (TRP) are localized in the amacrine neurons of the crayfish lamina ganglionaris. Indirect evidence suggests that GABA and TRP may be colocalized in these neurons. The extensive processes of the amacrine neurons occupy lamina layers containing the terminals of photoreceptors. Application of exogenous GABA and TRP to photoreceptor terminals produces a short-latency, dose-dependent hyperpolarization with a decay time constant on the order of a few seconds. TRP also exhibits actions that evolve over several minutes. These include a reduction of the receptor potential (and the light-elicited current) by approximately 40% and potentiation of the action of GABA by approximately 100%. The mechanisms of TRP action in crayfish are not known, but a plausible pathway is a TRP-dependent elevation of intracellular Ca(2+) that reduces photoreceptor sensitivity in arthropods. Although the mechanisms are not established, the results indicate that in crayfish photoreceptors TRP displays actions on two time scales and can exert profound modulatory control over cell function.
Indexed as
Identifiers
10684879PMC6772939W1711890983What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.