ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2000
A fundamental role for the nitric oxide-G-kinase signaling pathway in mediating intercellular Ca(2+) waves in glia.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 113 citations in OpenAlex.
- Spatial and temporal activation of spinal glial cells: role of gliopathy in central neuropathic pain following spinal cord injury in rats.Experimental neurology · 2012Pooled it
- The Interplay between cGMP and Calcium Signaling in Alzheimer's Disease.International journal of molecular sciences · 2022Review
- Expression of theJournal of neurogenetics · 2021Article
- Deregulation of CaInternational journal of molecular sciences · 2021Article
- Nitric Oxide/Cyclic GMP-Dependent Calcium Signalling Mediates IL-6- and TNF-α-Induced Expression of Glial Fibrillary Acid Protein.Journal of molecular neuroscience : MN · 2021Article
- Cx43 channels and signaling via IPCell death & disease · 2020Article
- NO as a multimodal transmitter in the brain: discovery and current status.British journal of pharmacology · 2019Review
- Plasticity of Neuron-Glial Transmission: Equipping Glia for Long-Term Integration of Network Activity.Neural plasticity · 2015Review
- A Zebrafish Drug-Repurposing Screen Reveals sGC-Dependent and sGC-Independent Pro-Inflammatory Activities of Nitric Oxide.PloS one · 2015Article
- Neuronal-glial Interactions Define the Role of Nitric Oxide in Neural Functional Processes.Current neuropharmacology · 2012Article
- Intercellular Ca(2+) waves: mechanisms and function.Physiological reviews · 2012Review
- Angiotensin II type 2 receptor-coupled nitric oxide production modulates free radical availability and voltage-gated Ca2+ currents in NTS neurons.American journal of physiology. Regulatory, integrative and comparative physiology · 2012Article
- Role of nitric oxide in cerebellar development and function: focus on granule neurons.Cerebellum (London, England) · 2012Review
- The complex contribution of NOS interneurons in the physiology of cerebrovascular regulation.Frontiers in neural circuits · 2012Article
- Article
- Regulation of radial glial motility by visual experience.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Regulation and function of cyclic GMP-mediated pathways in glial cells.Neurochemical research · 2008Review
- Concepts of neural nitric oxide-mediated transmission.The European journal of neuroscience · 2008Review
- A calcium-induced calcium influx factor, nitric oxide, modulates the refilling of calcium stores in astrocytes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Neuronal activity regulates correlated network properties of spontaneous calcium transients in astrocytes in situ.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, we highlight a role for the nitric oxide-cGMP-dependent protein kinase (NO-G-kinase) signaling pathway in glial intercellular Ca(2+) wave initiation and propagation. Addition of the NO donor molsidomine (100-500 microM) or puffing aqueous NO onto primary glial cell cultures evoked an increase in [Ca(2+)](i) in individual cells and also local intercellular Ca(2+) waves, which persisted after removal of extracellular Ca(2+). High concentrations of ryanodine (100-200 microM) and antagonists of the NO-G-kinase signaling pathway essentially abrogated the NO-induced increase in [Ca(2+)](i), indicating that NO mobilizes Ca(2+) from a ryanodine receptor-linked store, via the NO-G-kinase signaling pathway. Addition of 10 microM nicardipine to cells resulted in a slowing of the molsidomine-induced rise in [Ca(2+)](i), and inhibition of Mn(2+) quench of cytosolic fura-2 fluorescence mediated by a bolus application of 2 microM aqueous NO to cells, indicating that NO also induces Ca(2+) influx in glia. Mechanical stress of individual glial cells resulted in an increase in intracellular NO in target and neighboring cells and intercellular Ca(2+) waves, which were NO, cGMP, and G-kinase dependent, because incubating cells with nitric oxide synthase, guanylate cyclase, and G-kinase inhibitors, or NO scavengers, reduced Delta[Ca(2+)](i) and the rate of Ca(2+) wave propagation in these cultures. Results from this study suggest that NO-G-kinase signaling is coupled to Ca(2+) mobilization and influx in glial cells and that this pathway plays a fundamental role in the generation and propagation of intercellular Ca(2+) waves in glia.
Indexed as
Identifiers
10684878PMC6772944W2097254737What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.