Evidence map›Paper›PMID 10684298›Full record

ArticleJournal of virology2000

Herpesvirus mRNAs are sorted for export via Crm1-dependent and -independent pathways.

T M Soliman, S J Silverstein

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 60 citations in OpenAlex.

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  19. Viral regulation of mRNA export.Journal of virology · 2004
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

T M SolimanDepartment of Microbiology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA.
S J Silverstein
Columbia University · US

Funding

GENETIC AND BIOCHEMICAL STUDIES OF THE HSV IE-O GENER01AI033952 · NIAID · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI SILVERSTEIN, SAUL J · 1994 to 2003
$1.6M
NIAID NIH HHS AI-33952NIAID NIH HHS R01 AI033952
6 · The paper itself

Abstract

Cellular pre-mRNA splicing is inhibited by ICP27, a herpes simplex virus regulatory protein, resulting in the shutoff of host protein synthesis. Here we reveal that ICP27 also mediates the export of some virus RNAs via a Crm1-dependent pathway and present evidence that independent domains are required for these functions. Sorting of some viral mRNAs for nuclear export requires Crm1, while other virus mRNAs are exported via another pathway.

Indexed as

KaryopherinsReceptors, Cytoplasmic and NuclearAmino Acid SequenceAnimalsBinding SitesBiological TransportCarrier ProteinsChlorocebus aethiopsExportin 1 ProteinHerpesvirus 1, HumanHumansImmediate-Early ProteinsMolecular Sequence DataRNA, MessengerRNA, ViralSequence Homology, Amino AcidCarrier ProteinsExportin 1 ProteinICP27 protein, human herpesvirus 1Immediate-Early ProteinsKaryopherinsReceptors, Cytoplasmic and NuclearRNA, MessengerRNA, Viral

Identifiers

PMID10684298
PMCPMC111772
OpenAlexW2088500742

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.