ArticleJournal of virology2000
Lymphotoxin-alpha-deficient mice can clear a productive infection with murine gammaherpesvirus 68 but fail to develop splenomegaly or lymphocytosis.
Article in Journal of virology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- Tertiary Lymphoid Organs at the Center Stage of Skin's Humoral Immunity.Immunological reviews · 2025Review
- Role of Fibroblast-Immune Crosstalk in Kidney, Lung, and Skin Tertiary Lymphoid Structures.Immunological reviews · 2025Review
- IKKα-Mediated Noncanonical NF-κB Signaling Is Required To Support Murine Gammaherpesvirus 68 LatencyJournal of virology · 2022Article
- The Absence of Lymphotoxin-α, a Herpesvirus Entry Mediator (HVEM) Ligand, Affects Herpes Simplex Virus 1 InfectionJournal of virology · 2019Article
- A Human Gain-of-Function STING Mutation Causes Immunodeficiency and Gammaherpesvirus-Induced Pulmonary Fibrosis in Mice.Journal of virology · 2019Article
- Review
- Interplay of Murine Gammaherpesvirus 68 with NF-kappaB Signaling of the Host.Frontiers in microbiology · 2016Review
- B-lymphocyte lineage cells and the respiratory system.The Journal of allergy and clinical immunology · 2013Review
- Characterization of omental immune aggregates during establishment of a latent gammaherpesvirus infection.PloS one · 2012Article
- Tumor necrosis factor receptor/tumor necrosis factor family members in antiviral CD8 T-cell immunity.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2010Review
- Targeting lymphocyte activation through the lymphotoxin and LIGHT pathways.Immunological reviews · 2008Review
- Ectopic lymphoid tissues and local immunity.Seminars in immunology · 2008Review
- Immunological tumor destruction in a murine melanoma model by targeted LTalpha independent of secondary lymphoid tissue.Cancer immunology, immunotherapy : CII · 2008Article
- Regulatory T cells interfere with the development of bronchus-associated lymphoid tissue.The Journal of experimental medicine · 2007Article
- LIGHT-related molecular network in the regulation of innate and adaptive immunity.Immunologic research · 2007Review
- Role of lymphotoxin and homeostatic chemokines in the development and function of local lymphoid tissues in the respiratory tract.Inmunologia (Barcelona, Spain : 1987) · 2007Article
- CD8 T cell recall responses are regulated by the tissue tropism of the memory cell and pathogen.Journal of immunology (Baltimore, Md. : 1950) · 2006Article
- Antibody-independent control of gamma-herpesvirus latency via B cell induction of anti-viral T cell responses.PLoS pathogens · 2006Article
- Role of lymphotoxin in experimental models of infectious diseases: potential benefits and risks of a therapeutic inhibition of the lymphotoxin-beta receptor pathway.Infection and immunity · 2005Review
- Protein kinase C theta is not essential for T-cell-mediated clearance of murine gammaherpesvirus 68.Journal of virology · 2005Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Respiratory challenge with murine gammaherpesvirus 68 (MHV-68) leads to an acute productive infection of the lung and a persistent latent infection in B lymphocytes, epithelia, and macrophages. The virus also induces splenomegaly and an increase in the number of activated CD8 T cells in the circulation. Lymphotoxin- alpha-deficient (LTalpha(-/-)) mice have no lymph nodes and have disrupted splenic architecture. Surprisingly, in spite of the severe defect in secondary lymphoid tissue, LTalpha(-/-) mice could clear a productive MHV-68 infection, although with delayed kinetics compared to wild-type mice, and could control latent infection. Cytotoxic T-cell activity was comparable in the lungs and spleens of LTalpha(-/-) and wild-type mice. However, splenic gamma interferon responses were substantially reduced in LTalpha(-/-) mice. Furthermore, LTalpha(-/-) mice failed to develop splenomegaly or lymphocytosis. Although germinal centers were absent, LTalpha(-/-) mice were able to class switch and showed significant virus-specific antibody titers. This work demonstrates that organized secondary lymphoid tissue is not an absolute requirement for the generation of immune responses to viral infections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.