ArticleJournal of virology2000
Regulation of adenovirus membrane penetration by the cytoplasmic tail of integrin beta5.
Article in Journal of virology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 82 citations in OpenAlex.
- Productive infection of the retinal pigment epithelium by SARS-CoV-2: Initial effects and consideration of long-term consequences.PNAS nexus · 2024Article
- The Revolving Door of Adenovirus Cell Entry: Not All Pathways Are Equal.Pharmaceutics · 2021Review
- Genetic Delivery and Gene Therapy in Pulmonary Hypertension.International journal of molecular sciences · 2021Review
- Designer Oncolytic Adenovirus: Coming of Age.Cancers · 2018Review
- Polysialic acid is a cellular receptor for human adenovirus 52.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Role of MyD88 in adenovirus keratitis.Immunology and cell biology · 2017Article
- Increased adenovirus Type 5 mediated transgene expression due to RhoB down-regulation.PloS one · 2014Article
- Development of adenovirus capsid proteins for targeted therapeutic delivery.Therapeutic delivery · 2013Review
- Host cell autophagy modulates early stages of adenovirus infections in airway epithelial cells.Journal of virology · 2013Article
- Intracellular transport of recombinant adeno-associated virus vectors.Gene therapy · 2012Review
- Coagulation factor IX mediates serotype-specific binding of species A adenoviruses to host cells.Journal of virology · 2011Article
- Article
- Adenovirus.Current topics in microbiology and immunology · 2010Review
- Up-regulation of integrin beta3 in radioresistant pancreatic cancer impairs adenovirus-mediated gene therapy.Cancer science · 2009Article
- Usage of integrin and heparan sulfate as receptors for mouse adenovirus type 1.Journal of virology · 2009Article
- Tumor antigen LRRC15 impedes adenoviral infection: implications for virus-based cancer therapy.Journal of virology · 2008Article
- Gene delivery to differentiated neurotypic cells with RGD and HIV Tat peptide functionalized polymeric nanoparticles.Biomaterials · 2006Article
- A membrane-destabilizing peptide in capsid protein L2 is required for egress of papillomavirus genomes from endosomes.Journal of virology · 2006Article
- Intracellular trafficking of nonviral vectors.Gene therapy · 2005Review
- Analysis of foot-and-mouth disease virus internalization events in cultured cells.Journal of virology · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Adenovirus (Ad) cell entry involves sequential interactions with host cell receptors that mediate attachment (CAR), internalization (alphavbeta3 and alphavbeta5), and penetration (alphavbeta5) of the endosomal membrane. These events allow the virus to deliver its genome to the nucleus. While integrins alphavbeta3 and alphavbeta5 both promote Ad internalization into cells, integrin alphavbeta5 selectively facilitates Ad-mediated membrane permeabilization and endosome rupture. In the experiments reported herein, we demonstrate that the intracellular domain of the integrin beta5 subunit specifically regulates Ad-mediated membrane permeabilization and gene delivery. CS-1 melanoma cells expressing a truncated integrin beta5 or a chimeric (beta5-beta3) cytoplasmic tail (CT) supported normal levels of Ad endocytosis but had reduced Ad-mediated gene delivery and membrane permeabilization relative to cells expressing a wild-type integrin beta5. Thin-section electron microscopy revealed that virion particles were capable of being endocytosed into cells expressing a truncated beta5CT, but they failed to escape cytoplasmic vesicles and translocate to the nucleus. Site-specific mutagenesis studies suggest that a C-terminal TVD motif in the beta5CT plays a major role in Ad membrane penetration.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.