ArticleJournal of virology2000
Immune responses following neonatal DNA vaccination are long-lived, abundant, and qualitatively similar to those induced by conventional immunization.
Article in Journal of virology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
27 citing papers in PubMed, 85 citations in OpenAlex.
- LAMP-1 Chimeric to HIV-1 p55Gag in the Immunization of Neonate Mice Induces an Early Germinal Center Formation and AID Expression.Vaccines · 2022Article
- Sphingosine kinase 2 restricts T cell immunopathology but permits viral persistence.The Journal of clinical investigation · 2020Article
- Novel recombinant DNA vaccine candidates for human respiratory syncytial virus: Preclinical evaluation of immunogenicity and protection efficiency.Human vaccines & immunotherapeutics · 2017Article
- Gene-based neonatal immune priming potentiates a mucosal adenoviral vaccine encoding mycobacterial Ag85B.Vaccine · 2016Article
- A ceramide analogue stimulates dendritic cells to promote T cell responses upon virus infections.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Self in vivo production of a synthetic biological drug CTLA4Ig using a minicircle vector.Scientific reports · 2014Article
- Maternal immunity enhances Mycoplasma hyopneumoniae vaccination induced cell-mediated immune responses in piglets.BMC veterinary research · 2014Article
- Neonatal NK cells target the mouse duct epithelium via Nkg2d and drive tissue-specific injury in experimental biliary atresia.The Journal of clinical investigation · 2009Article
- Comparing the ability of a series of viral protein-expressing plasmid DNAs to protect against H5N1 influenza virus.Virus genes · 2009Article
- Effects of IL-7 on memory CD8 T cell homeostasis are influenced by the timing of therapy in mice.The Journal of clinical investigation · 2008Article
- Immune modulation induced by tuberculosis DNA vaccine protects non-obese diabetic mice from diabetes progression.Clinical and experimental immunology · 2007Article
- Effector role of neonatal hepatic CD8+ lymphocytes in epithelial injury and autoimmunity in experimental biliary atresia.Gastroenterology · 2007Article
- Expression library immunization: a road map for discovery of vaccines against infectious diseases.Infection and immunity · 2005Review
- Longitudinal assessment of human immunodeficiency virus type 1 (HIV-1)-specific gamma interferon responses during the first year of life in HIV-1-infected infants.Journal of virology · 2005Article
- Mucosally delivered Salmonella live vector vaccines elicit potent immune responses against a foreign antigen in neonatal mice born to naive and immune mothers.Infection and immunity · 2004Article
- The injection of plasmid DNA in mouse muscle results in lifelong persistence of DNA, gene expression, and humoral response.Molecular biotechnology · 2004Article
- Coxsackievirus replication and the cell cycle: a potential regulatory mechanism for viral persistence/latency.Medical microbiology and immunology · 2004Article
- Coxsackievirus B3 and the neonatal CNS: the roles of stem cells, developing neurons, and apoptosis in infection, viral dissemination, and disease.The American journal of pathology · 2003Article
- Protective efficacy of anti-Helicobacter pylori immunity following systemic immunization of neonatal mice.Infection and immunity · 2003Article
- Neonates mount robust and protective adult-like CD8(+)-T-cell responses to DNA vaccines.Journal of virology · 2002Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Virus infections are devastating to neonates, and the induction of active antiviral immunity in this age group is an important goal. Here, we show that a single neonatal DNA vaccination induces cellular and humoral immune responses which are maintained for a significant part of the animal's life span. We employ a sensitive technique which permits the first demonstration and quantitation, directly ex vivo, of virus-specific CD8(+) T cells induced by DNA immunization. One year postvaccination, antigen-specific CD8(+) T cells were readily detectable and constituted 0.5 to 1% of all CD8(+) T cells. By several criteria-including cytokine production, perforin content, development of lytic ability, and protective capacity-DNA vaccine-induced CD8(+) memory T cells were indistinguishable from memory cells induced by immunization with a conventional (live-virus) vaccine. Analyses of long-term humoral immune responses revealed that, in contrast to the strong immunoglobulin G2a (IgG2a) skewing of the humoral response seen after conventional vaccination, IgG1 and IgG2a levels were similar in DNA-vaccinated neonatal and adult animals, indicating a balanced T helper response. Collectively, these results show that a single DNA vaccination within hours or days of birth can induce long-lasting CD8(+) T- and B-cell responses; there is no need for secondary immunization (boosting). Furthermore, the observed immune responses induced in neonates and in adults are indistinguishable by several criteria, including protection against virus challenge.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.