ArticleJournal of virology2000
Evolutionary rate and genetic drift of hepatitis C virus are not correlated with the host immune response: studies of infected donor-recipient clusters.
Article in Journal of virology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 55 citations in OpenAlex.
- Hepatitis C hypervariable region 1: association of reduced selection pressure in african americans with treatment failure.Digestive diseases and sciences · 2007Trial
- Review
- Hypervariable Region 1 in Envelope Protein 2 of Hepatitis C Virus: A Linchpin in Neutralizing Antibody Evasion and Viral Entry.Frontiers in immunology · 2018Review
- Article
- Advanced molecular surveillance of hepatitis C virus.Viruses · 2015Review
- Hepatitis C virus molecular evolution: transmission, disease progression and antiviral therapy.World journal of gastroenterology · 2014Review
- Unexpected maintenance of hepatitis C viral diversity following liver transplantation.Journal of virology · 2012Article
- Vaccination with dendritic cells pulsed with hepatitis C pseudo particles induces specific immune responses in mice.World journal of gastroenterology · 2012Article
- The mode and tempo of hepatitis C virus evolution within and among hosts.BMC evolutionary biology · 2011Article
- Within-host dynamics of the hepatitis C virus quasispecies population in HIV-1/HCV coinfected patients.PloS one · 2011Article
- Article
- Genetic drift of HIV populations in culture.PLoS genetics · 2009Article
- Hepatitis C virus envelope glycoprotein co-evolutionary dynamics during chronic hepatitis C.Virology · 2008Article
- Sequence diversity of hepatitis C virus: implications for immune control and therapy.World journal of gastroenterology · 2007Review
- Compartmentalization of hepatitis C virus quasispecies in blood mononuclear cells of patients with mixed cryoglobulinemic syndrome.Journal of virology · 2005Article
- Wide range of quasispecies diversity during primary hepatitis C virus infection.Journal of virology · 2005Article
- Genetic evolution of structural region of hepatitis C virus in primary infection.World journal of gastroenterology · 2002Article
- Complement-mediated enhancement of antibody function for neutralization of pseudotype virus containing hepatitis C virus E2 chimeric glycoprotein.Journal of virology · 2002Article
- Molecular evolution of Puumala hantavirus.Journal of virology · 2001Article
- Production and characterization of monoclonal antibodies specific for a conserved epitope within hepatitis C virus hypervariable region 1.Journal of virology · 2001Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Six donor-recipient clusters of hepatitis C virus (HCV)-infected individuals were studied. For five clusters the period of infection of the donor could be estimated, and for all six clusters the time of infection of the recipients from the donor via blood transfusion was also precisely known. Detailed phylogenetic analyses were carried out to investigate the genomic evolution of the viral quasispecies within infected individuals in each cluster. The molecular clock analysis showed that HCV quasispecies within a patient are evolving at the same rate and that donors that have been infected for longer time tend to have a lower evolutionary rate. Phylogenetic analysis based on the split decomposition method revealed different evolutionary patterns in different donor-recipient clusters. Reactivity of antibody against the first hypervariable region (HVR1) of HCV in donor and recipient sera was evaluated and correlated to the calculated evolutionary rate. Results indicate that anti-HVR1 reactivity was related more to the overall level of humoral immune response of the host than to the HVR1 sequence itself, suggesting that the particular sequence of the HVR1 peptides is not the determinant of reactivity. Moreover, no correlation was found between the evolutionary rate or the heterogeneity of the viral quasispecies in the patients and the strength of the immune response to HVR1 epitopes. Rather, the results seem to imply that genetic drift is less dependent on immune pressure than on the rate of evolution and that the genetic drift of HCV is independent of the host immune pressure.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.