ArticleBritish journal of cancer2000
Lobular carcinoma in situ of the breast is not caused by constitutional mutations in the E-cadherin gene.
Article in British journal of cancer, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Breast cancer guidelines for Uganda (2nd Edition 2008).African health sciences · 2008Guideline
- Bilateral Prophylactic and Contralateral Risk-Reducing Mastectomy in Women With Germline CDH1 Pathogenic or Likely-Pathogenic Variants.Journal of surgical oncology · 2026Review
- Article
- CDH1 Gene and Hereditary Diffuse Gastric Cancer Syndrome: Molecular and Histological Alterations and Implications for Diagnosis And Treatment.Frontiers in pharmacology · 2018Review
- CDH1 germline mutations and hereditary lobular breast cancer.Familial cancer · 2016Review
- Germline CDH1 mutations in bilateral lobular carcinoma in situ.British journal of cancer · 2014Article
- Cadherin-catenin complex dissociation in lobular neoplasia of the breast.Breast cancer research and treatment · 2012Article
- Hereditary diffuse gastric cancer: association with lobular breast cancer.Familial cancer · 2008Review
- Germline E-cadherin mutations in familial lobular breast cancer.Journal of medical genetics · 2007Article
- CDH1 truncating mutations in the E-cadherin gene: an indication for total gastrectomy to treat hereditary diffuse gastric cancer.Annals of surgery · 2007Article
- Germline E-cadherin mutations in hereditary diffuse gastric cancer: assessment of 42 new families and review of genetic screening criteria.Journal of medical genetics · 2004Article
- The diagnosis and management of pre-invasive breast disease: genetic alterations in pre-invasive lesions.Breast cancer research : BCR · 2003Review
- E-cadherin and loss of heterozygosity at chromosome 16 in breast carcinogenesis: different genetic pathways in ductal and lobular breast cancer?Breast cancer research : BCR · 2002Review
- Low frequency of E-cadherin alterations in familial breast cancer.Breast cancer research : BCR · 2001Article
- The E-cadherin/catenin complex: an important gatekeeper in breast cancer tumorigenesis and malignant progression.Breast cancer research : BCR · 2001Review
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lobular carcinoma in situ (LCIS) is an unusual histological pattern of non-invasive neoplastic disease of the breast occurring predominantly in women aged between 40 and 50 years. LCIS is frequently multicentric and bilateral, and there is evidence that it is associated with an elevated familial risk of breast cancer. Although women with LCIS suffer an increased risk of invasive breast disease, this risk is moderate suggesting that LCIS may result from mutation of a gene or genes conferring a high risk of LCIS, but a lower risk of invasive breast cancer. The high frequency of somatic mutations in E-cadherin in LCIS, coupled with recent reports that germline mutations in this gene can predispose to diffuse gastric cancer, raised the possibility that constitutional E-cadherin mutations may confer susceptibility to LCIS. In order to explore this possibility we have examined a series of 65 LCIS patients for germline E-cadherin mutations. Four polymorphisms were detected but no pathogenic mutations were identified. The results indicate that E-cadherin is unlikely to act as a susceptibility gene for LCIS.
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