ArticleProceedings of the National Academy of Sciences of the United States of America2000
Vitamin E reduces chromosomal damage and inhibits hepatic tumor formation in a transgenic mouse model.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 154 citations in OpenAlex.
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- Genome-wide association study and high-quality gene mining related to soybean protein and fat.BMC genomics · 2023Article
- The genotoxic effects of perchloroethylene in human peripheral blood lymphocytes and the possible ameliorative role of α-tocopherol.Environmental science and pollution research international · 2021Article
- Tumor cell-activated "Sustainable ROS Generator" with homogeneous intratumoral distribution property for improved anti-tumor therapy.Theranostics · 2021Article
- Pathogenesis of Human Immunodeficiency Virus-Journal of clinical medicine · 2020Review
- HIV-1 Reverse Transcriptase Promotes Tumor Growth and Metastasis Formation via ROS-Dependent Upregulation of Twist.Oxidative medicine and cellular longevity · 2019Article
- Article
- A historic study that opened a new chapter in nutritional science.Acta pharmacologica Sinica · 2016Article
- Fluorescence probes to detect lipid-derived radicals.Nature chemical biology · 2016Article
- Prevention of hepatocellular carcinoma: Focusing on antioxidant therapy.World journal of hepatology · 2015Review
- Romo1 is associated with ROS production and cellular growth in human gliomas.Journal of neuro-oncology · 2015Article
- Association of serum α-tocopherol, β-carotene, and retinol with liver cancer incidence and chronic liver disease mortality.British journal of cancer · 2014Article
- In vivo detection of a novel endogenous etheno-DNA adduct derived from arachidonic acid and the effects of antioxidants on its formation.Free radical biology & medicine · 2014Article
- Oxidative stress and hepatic Nox proteins in chronic hepatitis C and hepatocellular carcinoma.Free radical biology & medicine · 2014Review
- Role of DLC1 tumor suppressor gene and MYC oncogene in pathogenesis of human hepatocellular carcinoma: potential prospects for combined targeted therapeutics (review).International journal of oncology · 2012Review
- Problems with using the normal distribution--and ways to improve quality and efficiency of data analysis.PloS one · 2011Article
- Tocotrienol-rich fraction prevents cell cycle arrest and elongates telomere length in senescent human diploid fibroblasts.Journal of biomedicine & biotechnology · 2011Article
- Tocopherol transfer protein sensitizes prostate cancer cells to vitamin E.The Journal of biological chemistry · 2010Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
We have previously shown that chronic activation of mitogenic signaling induced by over-expression of c-myc and transforming growth factor-alpha (TGFalpha) transgenes in mouse liver induces a state of oxidative stress. We therefore proposed that increased reactive oxygen species (ROS) generation might be responsible for the extensive chromosomal damage and acceleration of hepatocarcinogenesis characteristic for TGFalpha/c-myc mice. In this study, we show that vitamin E (VE), a potent free radical scavenging antioxidant, is able to protect liver tissue against oxidative stress and suppress tumorigenic potential of c-myc oncogene. Dietary supplementation with VE, starting from weaning, decreased ROS generation coincident with a marked inhibition of hepatocyte proliferation while increasing the chromosomal as well as mtDNA stability in the liver. Similarly, dietary VE reduced liver dysplasia and increased viability of hepatocytes. At 6 mo of age, VE treatment decreased the incidence of adenomas by 65% and prevented malignant conversion. These results indicate that ROS generated by over-expression of c-myc and TGFalpha in the liver are the primary carcinogenic agents in this animal model. Furthermore, the data demonstrate that dietary supplementation of VE can effectively inhibit liver cancer development.
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